1jux: Difference between revisions

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[[Image:1jux.gif|left|200px]]
{{Seed}}
[[Image:1jux.png|left|200px]]


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{{STRUCTURE_1jux|  PDB=1jux  |  SCENE=  }}  
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'''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''
===1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side===




==Overview==
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The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.
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{{ABSTRACT_PUBMED_14646114}}


==About this Structure==
==About this Structure==
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[[Category: Octamer]]
[[Category: Octamer]]
[[Category: Side-by-side]]
[[Category: Side-by-side]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:57:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:56:30 2008''

Revision as of 17:56, 1 July 2008

File:1jux.png

Template:STRUCTURE 1jux

1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side

Template:ABSTRACT PUBMED 14646114

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:14646114

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