1jvs: Difference between revisions

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[[Image:1jvs.gif|left|200px]]
{{Seed}}
[[Image:1jvs.png|left|200px]]


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{{STRUCTURE_1jvs|  PDB=1jvs  |  SCENE=  }}  
{{STRUCTURE_1jvs|  PDB=1jvs  |  SCENE=  }}  


'''Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs'''
===Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs===




==Overview==
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The key enzyme in the nonmevalonate pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), has been shown to be an effective target of antimalarial drugs. Here we report the crystal structure of DXR complexed with NADPH and a sulfate ion from Escherichia coli at 2.2 A resolution. The structure showed the presence of an extra domain, which is absent from other NADPH-dependent oxidoreductases, in addition to the conformation of catalytic residues and the substrate binding site. A flexible loop covering the substrate binding site plays an important role in the enzymatic reaction and the determination of substrate specificity.
The line below this paragraph, {{ABSTRACT_PUBMED_11872159}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11872159}}


==About this Structure==
==About this Structure==
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[[Category: Nadph]]
[[Category: Nadph]]
[[Category: Reductoisomerase]]
[[Category: Reductoisomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:59:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:01:56 2008''
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