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[[Image:1jxs.gif|left|200px]]
{{Seed}}
[[Image:1jxs.png|left|200px]]


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{{STRUCTURE_1jxs|  PDB=1jxs  |  SCENE=  }}  
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'''Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor'''
===Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor===




==Overview==
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Interleukin enhancer binding factor (ILF) binds to the interleukin-2 (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D structure of the DNA-binding domain of ILF was determined by multidimensional NMR spectroscopy. NMR structure analysis revealed that the DNA-binding domain of ILF is a new member of the winged helix/forkhead family, and that its wing 2 contains an extra alpha-helix. This is the first study to report the presence of a C-terminal alpha-helix in place of a typical wing 2 in a member of this family. This structural difference may be responsible for the different DNA-binding specificity of ILF compared to other winged helix/forkhead proteins. Our deletion studies of the fragments of ILF also suggest that the C-terminal region plays a regulatory role in DNA binding.
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{{ABSTRACT_PUBMED_12402362}}


==About this Structure==
==About this Structure==
1JXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXS OCA].  
1JXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXS OCA].  


==Reference==
==Reference==
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[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
[[Category: Winged helix]]
[[Category: Winged helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:03:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:40:47 2008''

Revision as of 11:40, 29 July 2008

File:1jxs.png

Template:STRUCTURE 1jxs

Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor

Template:ABSTRACT PUBMED 12402362

About this Structure

1JXS is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)., Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ, Proteins. 2002 Dec 1;49(4):543-53. PMID:12402362

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