1jy6: Difference between revisions

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[[Image:1jy6.gif|left|200px]]
{{Seed}}
[[Image:1jy6.png|left|200px]]


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{{STRUCTURE_1jy6|  PDB=1jy6  |  SCENE=  }}  
{{STRUCTURE_1jy6|  PDB=1jy6  |  SCENE=  }}  


'''B4DIMERA: A DE NOVO DESIGNED FOUR-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND'''
===B4DIMERA: A DE NOVO DESIGNED FOUR-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===




==Overview==
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The design and characterization of an open eight-stranded beta-sheet in a synthetic, 2-fold symmetric 70-residue peptide is described. The design strategy involves the generation of a 35-residue four-stranded beta-sheet peptide in which successive hairpins are nucleated by appropriately positioned (D)Pro-Xxx sequences. Oxidative dimerization using a single Cys residue positioned at the center of the C-terminal strand results in a disulfide-bridged eight-stranded structure. Nuclear Overhauser effects firmly establish an eight-stranded beta-sheet in methanol. In water, the outer strands are frayed, but a well-defined four-stranded beta-sheet stabilized by a disulfide bridge and a hydrophobic cluster is determined from NMR data. Comparison of the precursor peptide with the disulfide-bridged dimer reveals considerable enhancement of beta-sheet content in the latter, suggesting that the disulfide cross-link is an effective strategy for the stabilization of beta-sheets.
The line below this paragraph, {{ABSTRACT_PUBMED_11982362}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11982362 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11982362}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY6 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY6 OCA].  


==Reference==
==Reference==
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[[Category: Disulfide bond]]
[[Category: Disulfide bond]]
[[Category: Four-stranded beta-sheet]]
[[Category: Four-stranded beta-sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:04:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:11:46 2008''

Revision as of 18:11, 28 July 2008

File:1jy6.png

Template:STRUCTURE 1jy6

B4DIMERA: A DE NOVO DESIGNED FOUR-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND

Template:ABSTRACT PUBMED 11982362

About this Structure

Full experimental information is available from OCA.

Reference

Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge., Venkatraman J, Nagana Gowda GA, Balaram P, J Am Chem Soc. 2002 May 8;124(18):4987-94. PMID:11982362

Page seeded by OCA on Mon Jul 28 21:11:46 2008

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