Sandbox Reserved 1790: Difference between revisions

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{{Template:CH462_Biochemistry_II_2023}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{BAMBED
==Your Heading Here (maybe something like 'Structure')==
|DATE=June 14, 2016
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
|OLDID=2607465
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
|BAMBEDDOI=10.1002/bmb.21026
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
}}
 
==Lysophosphatidic Acid Receptor 1==
 
 
== Introduction ==
'''Lysophosphatidic Acid Receptor'''  
*[[Lipid signaling]]
*[[Transmembrane (cell surface) receptors]]
 
[[Image:LPA_in_membrane4.fw.png|200px|center|thumb|'''Figure 1:''' LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.]] 
 
== Lysophosphatidic Acid ==
[[Image:LPA.png|220px|left|thumb|'''Figure 2:''' Chemical Structure of LPA (monoacyl-sn-glycero-3-phosphate)]]
 
 
 
== Structure ==
 
 
 
=== Structural Stabilization ===
 
 
=== Key Ligand Interactions ===
[[Image:Amphbindingfinal.png|275 px|right|thumb|'''Figure 3''': Electrostatic illustration of the amphipathic binding pocket of the LPA<sub>1</sub> receptor. This binding pocket was revealed by cutting away the exterior or the protein. This binding pocket, located in the interior of the protein, has both polar and nonpolar regions. The blue and red coloration highlight the positively and negatively charged regions, respectively, and the white color shows the nonpolar region of the binding pocket.]]
 


== Function ==
== Function ==


== Disease ==
== Receptor Comparison ==
 
=== Sphingosine 1-Phosphate Receptor ===
 
 
 
 
=== Endocannabinoid Receptor 1 ===


== Relevance ==


== Structural highlights ==


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


</StructureSection>
 
== Disease Relevance ==
 
=== Cancer ===
 
===Pain===
 
=== Fibrosis ===
 
==3D structures of lysophosphatidic acid receptor==
 
[[4z34]], [[4z35]], [[4z36]] - hLPA1 + antagonist - human<br />
[[2lq4]] – hLPA1 second extracellular loop – NMR<br />
[[4p0c]] – hLPA2/NHERF2<br />
[[5xsz]] – LPA6A (mutant) – zebra fish<br />
 
== References ==
== References ==
<references/>
<references/>
==Proteopedia Resources==
[http://proteopedia.org/wiki/index.php/Category:Lysophosphatidic_acid_binding Category:Lysophosphatidic acid binding]
[http://proteopedia.org/wiki/index.php/Category:Lysophosphatidic_acid Category:Lysophosphatidic acid]
[http://proteopedia.org/wiki/index.php/User:R._Jeremy_Johnson/CH462:Biochemistry_II_Butler_University Butler University Proteopedia Pages]
See also:
*[[Receptor]]
*[[Transmembrane (cell surface) receptors]]
*[[G protein-coupled receptors]]
</StructureSection>
==Student Contributors==
Heather Hansen
Stephanie Kuhlman
Chandler Mitchell
Clayton Taylor
[[Category:Featured in BAMBED]]
[[Category:Topic Page]]

Revision as of 16:32, 17 March 2023

This page, as it appeared on June 14, 2016, was featured in this article in the journal Biochemistry and Molecular Biology Education.


Lysophosphatidic Acid Receptor 1

Introduction

Lysophosphatidic Acid Receptor

Figure 1: LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.

Lysophosphatidic Acid

Figure 2: Chemical Structure of LPA (monoacyl-sn-glycero-3-phosphate)


Structure

Structural Stabilization

Key Ligand Interactions

Figure 3: Electrostatic illustration of the amphipathic binding pocket of the LPA1 receptor. This binding pocket was revealed by cutting away the exterior or the protein. This binding pocket, located in the interior of the protein, has both polar and nonpolar regions. The blue and red coloration highlight the positively and negatively charged regions, respectively, and the white color shows the nonpolar region of the binding pocket.


Function

Receptor Comparison

Sphingosine 1-Phosphate Receptor

Endocannabinoid Receptor 1

Disease Relevance

Cancer

Pain

Fibrosis

3D structures of lysophosphatidic acid receptor

4z34, 4z35, 4z36 - hLPA1 + antagonist - human
2lq4 – hLPA1 second extracellular loop – NMR
4p0c – hLPA2/NHERF2
5xsz – LPA6A (mutant) – zebra fish

References

Proteopedia Resources

Category:Lysophosphatidic acid binding

Category:Lysophosphatidic acid

Butler University Proteopedia Pages

See also:

</StructureSection>

Student Contributors

Heather Hansen

Stephanie Kuhlman

Chandler Mitchell

Clayton Taylor

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