1jy7: Difference between revisions

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[[Image:1jy7.gif|left|200px]]
{{Seed}}
[[Image:1jy7.png|left|200px]]


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{{STRUCTURE_1jy7|  PDB=1jy7  |  SCENE=  }}  
{{STRUCTURE_1jy7|  PDB=1jy7  |  SCENE=  }}  


'''THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME'''
===THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME===




==Overview==
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High-salt crystals of human oxy- and deoxyhaemoglobin have been studied at different levels of environmental humidity and solvent content. The structure of the oxy form remains relatively unchanged at all levels. The deoxy form, however, undergoes a water-mediated transformation when the relative humidity around the crystals is reduced below 93%. The space group is maintained during the transformation, but the unit-cell volume nearly doubles, with two tetrameric molecules in the asymmetric unit of the low-humidity form compared with one in the native crystals. Interestingly, the haem geometry in the low-humidity form is closer to that in the oxy form than to that in the native deoxy form. The quaternary structure of one of the tetramers moves slightly towards that in the oxy form, while that in the other is more different from the oxy form than that in the high-salt native deoxy form. Thus, it would appear that, as in the case of the liganded form, the deoxy form of haemoglobin can also access an ensemble of related T states.
The line below this paragraph, {{ABSTRACT_PUBMED_12077435}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12077435}}


==About this Structure==
==About this Structure==
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[[Category: Human methemoglobin]]
[[Category: Human methemoglobin]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:04:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:49:29 2008''

Revision as of 13:49, 28 July 2008

File:1jy7.png

Template:STRUCTURE 1jy7

THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME

Template:ABSTRACT PUBMED 12077435

About this Structure

1JY7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state., Biswal BK, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1155-61. Epub 2002, Jun 20. PMID:12077435

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