8c8d: Difference between revisions
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==Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).== | |||
<StructureSection load='8c8d' size='340' side='right'caption='[[8c8d]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U2C:(2~{R})-3-[6-chloranyl-2-(furan-2-ylmethylamino)quinazolin-4-yl]-2-methyl-~{N}-oxidanyl-propanamide'>U2C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8d OCA], [https://pdbe.org/8c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8d RCSB], [https://www.ebi.ac.uk/pdbsum/8c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8d ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Baddock HT]] | |||
[[Category: Bielinski M]] | |||
[[Category: Bountra C]] | |||
[[Category: Gileadi O]] | |||
[[Category: McHugh PJ]] | |||
[[Category: Newman JA]] | |||
[[Category: Schofield CJ]] | |||
[[Category: Yosaatmadja Y]] | |||
[[Category: Von Delft F]] | |||
Revision as of 11:40, 1 February 2024
Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).
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