1irk: Difference between revisions

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[[Image:1irk.gif|left|200px]]<br />

[[Image:1irk.gif|left|200px]]<br /><applet load="1irk" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1irk" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1irk, resolution 2.1Å" />

'''CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR'''<br />

==Overview==

The X-ray crystal structure of the tyrosine kinase domain of the human, insulin receptor has been determined by multiwavelength anomalous, diffraction phasing and refined to 2.1 A resolution. The structure reveals, the determinants of substrate preference for tyrosine rather than serine, or threonine and a novel autoinhibition mechanism whereby one of the, tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is, bound in the active site.

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

==Disease==

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==About this Structure==

1IRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EMC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1IRK OCA].

1IRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=EMC:'>EMC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRK OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Ellis, L.]]

[[Category: Hendrickson, W.A.]]

[[Category: Hendrickson, W A.]]

[[Category: Hubbard, S.R.]]

[[Category: Hubbard, S R.]]

[[Category: Wei, L.]]

[[Category: EMC]]

[[Category: transferase (phosphotransferase)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:33:~~58 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:14:50 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1irk.gif|left|200px]]<br />
+[[Image:1irk.gif|left|200px]]<br /><applet load="1irk" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1irk" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1irk, resolution 2.1&Aring;" />
 '''CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR'''<br />
 ==Overview==
-The X-ray crystal structure of the tyrosine kinase domain of the human, insulin receptor has been determined by multiwavelength anomalous, diffraction phasing and refined to 2.1 A resolution. The structure reveals, the determinants of substrate preference for tyrosine rather than serine, or threonine and a novel autoinhibition mechanism whereby one of the, tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is, bound in the active site.
+The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-IRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EMC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IRK OCA].
+IRK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=EMC:'>EMC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRK OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Ellis, L.]]
-[[Category: Hendrickson, W.A.]]
+[[Category: Hendrickson, W A.]]
-[[Category: Hubbard, S.R.]]
+[[Category: Hubbard, S R.]]
 [[Category: Wei, L.]]
 [[Category: EMC]]
 [[Category: transferase (phosphotransferase)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:33:58 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:14:50 2008''