1k05: Difference between revisions

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[[Image:1k05.~~jpg~~|left|200px]]

[[Image:1k05.png|left|200px]]

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~~'''~~Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase~~'''~~

===Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase===

~~==Overview==~~

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The ~~localization of focal adhesion kinase (FAK)~~ to ~~sites of integrin clustering initiates downstream signaling. The C-terminal focal adhesion targeting~~ (~~FAT) domain causes this localization by interacting with talin and paxillin~~. ~~FAT also mediates signaling through Grb2 via phosphorylated Y925~~. ~~We report two crystal structures of~~ the ~~FAT domain~~. ~~Large rearrangements of the structure are indicated to allow phosphorylation of Y925 and subsequent interaction with Grb2. Sequence homology and structural compatibility suggest a FAT~~-~~like fold for the C~~-terminal domains of CAS, Efs/Sin, and HEF1. A structure-based alignment including these proteins and the vinculin tail domain reveals a conserved region that could play a role in focal adhesion targeting. Previously postulated "paxillin binding subdomains" may contribute to structural integrity rather than directly to paxillin binding.

The line below this paragraph, {{ABSTRACT_PUBMED_12005431}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12005431 is the PubMed ID number.

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==About this Structure==

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[[Category: Noble, M E.M.]]

[[Category: Up-down-up-down four helical bundle]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 22~~:08:09 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:27:31 2008''

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-[[Image:1k05.jpg|left|200px]]
+{{Seed}}
+[[Image:1k05.png|left|200px]]
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 {{STRUCTURE_1k05|  PDB=1k05  |  SCENE=  }}
-'''Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase'''
+===Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase===
-==Overview==
+<!--
-The localization of focal adhesion kinase (FAK) to sites of integrin clustering initiates downstream signaling. The C-terminal focal adhesion targeting (FAT) domain causes this localization by interacting with talin and paxillin. FAT also mediates signaling through Grb2 via phosphorylated Y925. We report two crystal structures of the FAT domain. Large rearrangements of the structure are indicated to allow phosphorylation of Y925 and subsequent interaction with Grb2. Sequence homology and structural compatibility suggest a FAT-like fold for the C-terminal domains of CAS, Efs/Sin, and HEF1. A structure-based alignment including these proteins and the vinculin tail domain reveals a conserved region that could play a role in focal adhesion targeting. Previously postulated "paxillin binding subdomains" may contribute to structural integrity rather than directly to paxillin binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_12005431}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12005431 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12005431}}
 ==About this Structure==
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 [[Category: Noble, M E.M.]]
 [[Category: Up-down-up-down four helical bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:08:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:27:31 2008''