1k09: Difference between revisions

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[[Image:1k09.jpg|left|200px]]
{{Seed}}
[[Image:1k09.png|left|200px]]


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{{STRUCTURE_1k09|  PDB=1k09  |  SCENE=  }}  
{{STRUCTURE_1k09|  PDB=1k09  |  SCENE=  }}  


'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein'''
===Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein===




==Overview==
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BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.
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(as it appears on PubMed at http://www.pubmed.gov), where 12021452 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12021452}}


==About this Structure==
==About this Structure==
1K09 is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].  
1K09 is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA].  


==Reference==
==Reference==
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[[Category: Woodward, C.]]
[[Category: Woodward, C.]]
[[Category: Four-stranded antiparallel beta-sheet]]
[[Category: Four-stranded antiparallel beta-sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:08:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:18:52 2008''

Revision as of 19:19, 28 July 2008

File:1k09.png

Template:STRUCTURE 1k09

Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein

Template:ABSTRACT PUBMED 12021452

About this Structure

1K09 is a Protein complex structure. Full experimental information is available from OCA.

Reference

BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452

Page seeded by OCA on Mon Jul 28 22:18:52 2008

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