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| {{STRUCTURE_1k1a| PDB=1k1a | SCENE= }} | | {{STRUCTURE_1k1a| PDB=1k1a | SCENE= }} |
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| '''Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family'''
| | ===Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family=== |
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| ==Overview==
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| IkappaB proteins associate with the transcription factor NF-kappaB via their ankyrin repeat domain. Bcl-3 is an unusual IkappaB protein because it is primarily nucleoplasmic and can lead to enhanced NF-kappaB-dependent transcription, unlike the prototypical IkappaB protein IkappaBalpha, which inhibits NF-kappaB activity by retaining it in the cytoplasm. Here we report the 1.9 A crystal structure of the ankyrin repeat domain of human Bcl-3 and compare it with that of IkappaBalpha bound to NF-kappaB. The two structures are highly similar over the central ankyrin repeats but differ in the N-terminal repeat and at the C-terminus, where Bcl-3 contains a seventh repeat in place of the acidic PEST region of IkappaBalpha. Differences between the two structures suggest why Bcl-3 differs from IkappaBalpha in selectivity towards various NF-kappaB species, why Bcl-3 but not IkappaBalpha can associate with its NF-kappaB partner bound to DNA, and why two molecules of Bcl-3 but only one of IkappaBalpha can bind to its NF-kappaB partner. Comparison of the two structures thus provides an insight into the functional diversity of IkappaB proteins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11707390}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11707390 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11707390}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Ikappab protein]] | | [[Category: Ikappab protein]] |
| [[Category: Nf-kappab transcription factor]] | | [[Category: Nf-kappab transcription factor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:10:31 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:15:52 2008'' |
