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[[Image:1k28.jpg|left|200px]]
{{Seed}}
[[Image:1k28.png|left|200px]]


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{{STRUCTURE_1k28|  PDB=1k28  |  SCENE=  }}  
{{STRUCTURE_1k28|  PDB=1k28  |  SCENE=  }}  


'''The Structure of the Bacteriophage T4 Cell-Puncturing Device'''
===The Structure of the Bacteriophage T4 Cell-Puncturing Device===




==Overview==
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Bacteriophage T4 has a very efficient mechanism for infecting cells. The key component of this process is the baseplate, located at the end of the phage tail, which regulates the interaction of the tail fibres and the DNA ejection machine. A complex of gene product (gp) 5 (63K) and gp27 (44K), the central part of the baseplate, is required to penetrate the outer cell membrane of Escherichia coli and to disrupt the intermembrane peptidoglycan layer, promoting subsequent entry of phage DNA into the host. We present here a crystal structure of the (gp5-gp27)3 321K complex, determined to 2.9 A resolution and fitted into a cryo-electron microscopy map at 17 A resolution of the baseplate-tail tube assembly. The carboxy-terminal domain of gp5 is a triple-stranded beta-helix that forms an equilateral triangular prism, which acts as a membrane-puncturing needle. The middle lysozyme domain of gp5, situated on the periphery of the prism, serves to digest the peptidoglycan layer. The amino-terminal, antiparallel beta-barrel domain of gp5 is inserted into a cylinder formed by three gp27 monomers, which may serve as a channel for DNA ejection.
The line below this paragraph, {{ABSTRACT_PUBMED_11823865}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11823865 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11823865}}


==About this Structure==
==About this Structure==
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[[Category: T4 tail lysozyme]]
[[Category: T4 tail lysozyme]]
[[Category: Triple-stranded beta-helix]]
[[Category: Triple-stranded beta-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:25:35 2008''

Revision as of 18:25, 1 July 2008

File:1k28.png

Template:STRUCTURE 1k28

The Structure of the Bacteriophage T4 Cell-Puncturing Device

Template:ABSTRACT PUBMED 11823865

About this Structure

1K28 is a Protein complex structure of sequences from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Structure of the cell-puncturing device of bacteriophage T4., Kanamaru S, Leiman PG, Kostyuchenko VA, Chipman PR, Mesyanzhinov VV, Arisaka F, Rossmann MG, Nature. 2002 Jan 31;415(6871):553-7. PMID:11823865

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