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| {{STRUCTURE_1k2e| PDB=1k2e | SCENE= }} | | {{STRUCTURE_1k2e| PDB=1k2e | SCENE= }} |
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| '''crystal structure of a nudix protein from Pyrobaculum aerophilum'''
| | ===crystal structure of a nudix protein from Pyrobaculum aerophilum=== |
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| ==Overview==
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| Nudix proteins, formerly called MutT homolog proteins, are a large family of proteins that play an important role in reducing the accumulation of potentially toxic compounds inside the cell. They hydrolyze a wide variety of substrates that are mainly composed of a nucleoside diphosphate linked to some other moiety X and thus are called Nudix hydrolases. Here, the crystal structure of a Nudix hydrolase from the hyperthermophilic archaeon Pyrobaculum aerophilum is reported. The structure was determined by the single-wavelength anomalous scattering method with data collected at the peak anomalous wavelength of an iridium-derivatized crystal. It reveals an extensive dimer interface, with each subunit contributing two strands to the beta-sheet of the other subunit. Individual subunits consist of a mixed highly twisted and curved beta-sheet of 11 beta-strands and two alpha-helices, forming an alpha-beta-alpha sandwich. The conserved Nudix box signature motif, which contains the essential catalytic residues, is located at the first alpha-helix and the beta-strand and loop preceding it. The unusually short connections between secondary-structural elements, together with the dimer form of the structure, are likely to contribute to the thermostability of the P. aerophilum Nudix protein.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11914479}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11914479 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11914479}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Putative nudix hydrolase]] | | [[Category: Putative nudix hydrolase]] |
| [[Category: Structural genomic]] | | [[Category: Structural genomic]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:59 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:28:48 2008'' |
