1k2j: Difference between revisions

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[[Image:1k2j.gif|left|200px]]
{{Seed}}
[[Image:1k2j.png|left|200px]]


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{{STRUCTURE_1k2j|  PDB=1k2j  |  SCENE=  }}  
{{STRUCTURE_1k2j|  PDB=1k2j  |  SCENE=  }}  


'''NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2'''
===NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2===




==Overview==
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Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed.
The line below this paragraph, {{ABSTRACT_PUBMED_11922844}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11922844}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2J OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2J OCA].  


==Reference==
==Reference==
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[[Category: Lam, S L.]]
[[Category: Lam, S L.]]
[[Category: Self-complementary dna]]
[[Category: Self-complementary dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:32:45 2008''

Revision as of 18:32, 1 July 2008

File:1k2j.png

Template:STRUCTURE 1k2j

NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2

Template:ABSTRACT PUBMED 11922844

About this Structure

Full experimental information is available from OCA.

Reference

Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2)., Lam SL, Ip LN, J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844

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