8ceg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8ceg is ~~ON HOLD until Paper Publication~~

==BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling==

~~Authors~~: ~~Kajander~~, T., ~~Fudo~~, S., ~~Yan~~, Z.~~, Zhao, H~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[8ceg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEG FirstGlance]. <br>

~~Description~~: ~~BAR domain protein FAM92A1~~ essential for mitochondrial membrane ~~remodeling~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ceg OCA], [https://pdbe.org/8ceg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ceg RCSB], [https://www.ebi.ac.uk/pdbsum/8ceg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ceg ProSAT]</span></td></tr>

[[Category: ~~Kajander, T~~]]

</table>

[[Category: Fudo, S]]

== Disease ==

[[Category: ~~Zhao, H~~]]

[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Postaxial polydactyly type A. The disease may be caused by variants affecting the gene represented in this entry.

[[Category: Yan, Z]]

== Function ==

[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).[UniProtKB:Q8BP22]<ref>PMID:27528616</ref> <ref>PMID:30395363</ref> <ref>PMID:30404948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fudo S]]

[[Category: Kajander T]]

[[Category: Yan Z]]

[[Category: Zhao H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8ceg is ON HOLD  until Paper Publication
+==BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling==
+<StructureSection load='8ceg' size='340' side='right'caption='[[8ceg]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-Authors: Kajander, T., Fudo, S., Yan, Z., Zhao, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ceg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEG FirstGlance]. <br>
-Description: BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ceg OCA], [https://pdbe.org/8ceg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ceg RCSB], [https://www.ebi.ac.uk/pdbsum/8ceg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ceg ProSAT]</span></td></tr>
-[[Category: Kajander, T]]
+</table>
-[[Category: Fudo, S]]
+== Disease ==
-[[Category: Zhao, H]]
+[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Postaxial polydactyly type A. The disease may be caused by variants affecting the gene represented in this entry.
-[[Category: Yan, Z]]
+== Function ==
+[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).[UniProtKB:Q8BP22]<ref>PMID:27528616</ref> <ref>PMID:30395363</ref> <ref>PMID:30404948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fudo S]]
+[[Category: Kajander T]]
+[[Category: Yan Z]]
+[[Category: Zhao H]]