1k3k: Difference between revisions

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[[Image:1k3k.gif|left|200px]]
{{Seed}}
[[Image:1k3k.png|left|200px]]


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{{STRUCTURE_1k3k|  PDB=1k3k  |  SCENE=  }}  
{{STRUCTURE_1k3k|  PDB=1k3k  |  SCENE=  }}  


'''Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus'''
===Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus===




==Overview==
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Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. &amp; Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. &amp; Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 11904405 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11904405}}


==About this Structure==
==About this Structure==
1K3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA].  
1K3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA].  


==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Solution structure]]
[[Category: Solution structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:15:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 02:18:29 2008''

Revision as of 23:23, 1 July 2008

File:1k3k.png

Template:STRUCTURE 1k3k

Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus

Template:ABSTRACT PUBMED 11904405

About this Structure

1K3K is a Single protein structure of sequence from Human herpesvirus 8. Full experimental information is available from OCA.

Reference

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405

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