1k4j: Difference between revisions

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[[Image:1k4j.jpg|left|200px]]
{{Seed}}
[[Image:1k4j.png|left|200px]]


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{{STRUCTURE_1k4j|  PDB=1k4j  |  SCENE=  }}  
{{STRUCTURE_1k4j|  PDB=1k4j  |  SCENE=  }}  


'''Crystal Structure of the Acyl-homoserinelactone Synthase EsaI Complexed with Rhenate'''
===Crystal Structure of the Acyl-homoserinelactone Synthase EsaI Complexed with Rhenate===




==Overview==
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Synthesis and detection of acyl-homoserine lactones (AHLs) enables many gram-negative bacteria to engage in quorum sensing, an intercellular signaling mechanism that activates differentiation to virulent and biofilm lifestyles. The AHL synthases catalyze acylation of S-adenosyl-L-methionine by acyl-acyl carrier protein and lactonization of the methionine moiety to give AHLs. The crystal structure of the AHL synthase, EsaI, determined at 1.8 A resolution, reveals a remarkable structural similarity to the N-acetyltransferases and defines a common phosphopantetheine binding fold as the catalytic core. Critical residues responsible for catalysis and acyl chain specificity have been identified from a modeled substrate complex and verified through functional analysis in vivo. A mechanism for the N-acylation of S-adenosyl-L-methionine by 3-oxo-hexanoyl-acyl carrier protein is proposed.
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{{ABSTRACT_PUBMED_11931774}}


==About this Structure==
==About this Structure==
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[[Category: Mixed alpha beta]]
[[Category: Mixed alpha beta]]
[[Category: Quorum sensing]]
[[Category: Quorum sensing]]
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Revision as of 06:22, 2 July 2008

File:1k4j.png

Template:STRUCTURE 1k4j

Crystal Structure of the Acyl-homoserinelactone Synthase EsaI Complexed with Rhenate

Template:ABSTRACT PUBMED 11931774

About this Structure

1K4J is a Single protein structure of sequence from Pantoea stewartii subsp. stewartii. Full crystallographic information is available from OCA.

Reference

Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing., Watson WT, Minogue TD, Val DL, von Bodman SB, Churchill ME, Mol Cell. 2002 Mar;9(3):685-94. PMID:11931774

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