Lactoperoxidase

spinqualitylabelsall models Glycosylated bovine lactoferrin containing heme complex with thiocyanate, I- (purple) and Ca+2 (green) ions (PDB entry 3eri) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion. Relevance The short-lived oxidized intermediates of the LPO reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. Structural highlights The peroxidation of thiocyanate catalyzed by LPO occurs at the heme cavity site. Water molecules shown as red spheres. Whole active site.

3D structures of lactoperoxidase

Updated on 27-April-2023

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• Lactoperoxidase binary complex
  • 2pt3 - bPLO + phosphate - bovine
    
  • 2nqx, 5b72 – bPLO + I
    
  • 7dlq – bPLO + H2O2
    
  • 2r5l – gLPO + I – goat
    
  • 3nak – gLPO + formate
    
  • 6ky7, 7c73, 7c74, 7c75, 7d52, 7dao, 7de5, 7dmr – yPLO + Ca - yak
    
  • 7c74 - yLPO + Cl
    
  • 6l32, 6l42, 7d52, 6l5g, 7c75 - yLPO + Zn
    
  • 6lqw, 7y3u – yPLO + H2O2
    
  • 7c73 – yPLO + phosphoserine
    
• Lactoperoxidase ternary complex
  • 2ips, 3eri, 3gc1, 6a4y, 6lco, 6m7e, 7dn7 – bLPO + SCN + I
    
  • 2qrb – bLPO + SCN + Cl
    
  • 3bxi – bLPO + SCN + nitrate
    
  • 4pnx - bPLO + bromomethane + I
    
  • 2pum – bPLO + catechol + I
    
  • 3krq – bLPO + amino-triazole + I
    
  • 6kmk – bPLO + H2O2 + phosphoserine
    
  • 7dlq, 7dn6 – bPLO + H2O2 + I
    
  • 2z5z – wbPLO + F + I – water buffalo
    
  • 2o86 – wbPLO + nitrate + I
    
  • 3erh - wbLPO + SCN + I
    
  • 7de5 - yLPO + SCN + I
    
  • 2ojv – gPLO + CN + I
    
  • 3n8f - gLPO + SCN + nitrate
    
  • 5ff1 - gLPO + methimazole + nitrate
    
  • 5hpw - gLPO + propyl-thiouracil + nitrate
    
  • 3niu – gLPO + diethylene glycol + phosphate
    
  • 3rke - gPLO + inhibitor + I
    
  • 2ikc – sLPO + carbonate + formate – sheep
    
  • 7ve3 - sLPO + hypoiodite + I
    
• Lactoperoxidase quaternary complex
  • 3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
    
  • 3gck - bPLO + benzylhydroxamic acid + SCN + I
    
  • 3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
    
  • 3gcl, 2qqt - bPLO + aspirin + SCN + I
    
  • 3i6n - bPLO + isoniazid + SCN + I
    
  • 4ksz - bPLO + cystein + SCN + I
    
  • 5wv3 - bPLO + oxidosulfanyl-methanamine + Br + I
    
  • 7dlq - bPLO + Br + Cl + SCN + I
    
  • 7wyj - bPLO + indomethacin + SCN + I
    
  • 3py4, 6m7e - bPLO + paracetamol + SCN + I
    
  • 7dn6 - bPLO + phenyliso-SCN + SCN + I
    
  • 7dn7 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
    
  • 3s4f, 4njb, 6lco - bPLO + pyridine derivative + SCN + I
    
  • 3r4x, 5zgs - bPLO + pyrazine derivative + SCN + I
    
  • 3r5o - bPLO + methoxyphenol + SCN + I
    
  • 3tgy - bPLO + ascorbate + SCN + I
    
  • 3v6q - bPLO + CO + SCN + I
    
  • 6l9t - bLPO + Zn + OSCN + I
    
  • 5gls - bLPO + butyl-triazole + SCN + I
    
  • 5gh0 - bLPO + mercaptoimidazole + nitrate + carbonate
    
  • 2gjm - wbPLO + carbonate + SCN + I
    
  • 3faq – wbLPO + CN + SCN + I
    
  • 3fnl - wbPLO + salicylhydroxamic acid + SCN + I
    
  • 4y55 - wbLPO + rhodanide + SCN + I
    
  • 2e9e – gPLO + nitrate + carbonate + SCN + CN
    
  • 2efb – gPLO + phosphate + carbonate + SCN + CN
    
  • 3qf1 - gPLO + piperazine + SCN + I
    
  • 8ing - gPLO + acrylonitrile + SCN + I
    
  • 4msf, 4oek - gPLO + phenol derivative+ SCN + I
    
  • 2eha – gPLO + formate + carbonate + SCN
    
  • 3r55, 6lf7 - gPLO + pyrazine derivative + SCN + I
    
  • 3sxv - gPLO + amitrole + SCN + I
    
  • 4qjq - gPLO + octopamine + SCN + I
    
  • 6lf7 - gPLO + hypocyanite + SCN + H2O2 + I
    
  • 7ve3 - sPLO +tetrahydrofuran + SCN + I
    
  • 6ky7, 6l2j – yPLO + H2O2 + phosphoserine + SCN + I
    

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