Sandbox Reserved 1777: Difference between revisions

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USE THE ROCK BUT CHANGE HOW FAR IT ROCKS TO

Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a ~~conformational change ([~~[https://en.wikipedia.org/wiki/Conformational_change~~]][[~~conformational change]]) to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with ~~hydrogen bonding ([~~[https://en.wikipedia.org/wiki/Hydrogen_bond]][[hydrogen bonding]]) and ~~pi stacking ([~~[https://en.wikipedia.org/wiki/Stacking_(chemistry)]][[pi stacking]]). When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.

Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a [https://en.wikipedia.org/wiki/Conformational_change. conformational change] to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with [https://en.wikipedia.org/wiki/Hydrogen_bond]][[hydrogen bonding. hydrogen bonding] and [https://en.wikipedia.org/wiki/Stacking_(chemistry)]][[pi stacking. pi stacking]. When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.

== Disease ==

Sandbox Reserved 1777: Difference between revisions

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@@ Line 11: / Line 11: @@
 USE THE ROCK BUT CHANGE HOW FAR IT ROCKS TO
-Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a conformational change ([[https://en.wikipedia.org/wiki/Conformational_change]][[conformational change]]) to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with hydrogen bonding ([[https://en.wikipedia.org/wiki/Hydrogen_bond]][[hydrogen bonding]]) and pi stacking ([[https://en.wikipedia.org/wiki/Stacking_(chemistry)]][[pi stacking]]). When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.
+Switch I and II are located on MRAS. The switches determine whether MRAS can bind to SHOC2-PP1C. The switches have to go through a  [https://en.wikipedia.org/wiki/Conformational_change. conformational change] to allow binding of SHOC2-PP1C to MRAS. This conformational change is caused by GTP replacing GDP. Once GTP is added MRAS shifts and binds with SHOC2. When GDP is bound to MRAS switch II is moved outward which causes a steric clash with SHOC2. When GTP is bound, switch II can form various hydrophobic interactions with SHOC2. Interactions are strengthened with [https://en.wikipedia.org/wiki/Hydrogen_bond]][[hydrogen bonding. hydrogen bonding] and [https://en.wikipedia.org/wiki/Stacking_(chemistry)]][[pi stacking. pi stacking]. When MRAS is bound to SHOC2-PP1C, switch I has an important role in making interactions with PP1C.
 == Disease ==