1k64: Difference between revisions

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[[Image:1k64.jpg|left|200px]]
{{Seed}}
[[Image:1k64.png|left|200px]]


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{{STRUCTURE_1k64|  PDB=1k64  |  SCENE=  }}  
{{STRUCTURE_1k64|  PDB=1k64  |  SCENE=  }}  


'''NMR Structue of alpha-conotoxin EI'''
===NMR Structue of alpha-conotoxin EI===




==Overview==
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A high resolution structure of alpha-conotoxin EI has been determined by (1)H NMR spectroscopy and molecular modeling. alpha-Conotoxin EI has the same disulfide framework as alpha 4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the alpha 3/5 and alpha A conotoxins. The unique binding preference of alpha-conotoxin EI to the alpha(1)/delta subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various alpha-conotoxins possessing distinct receptor subtype specificities. Structural comparison of alpha-conotoxin EI with the gamma-subunit favoring alpha-conotoxin GI suggests that the Torpedo delta-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven alpha-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is approximately 20 A (height) x 20 A (width) x 15 A (thickness).
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(as it appears on PubMed at http://www.pubmed.gov), where 11641403 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11641403}}


==About this Structure==
==About this Structure==
1K64 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K64 OCA].  
1K64 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K64 OCA].  


==Reference==
==Reference==
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[[Category: Suk, J E.]]
[[Category: Suk, J E.]]
[[Category: Omega-shaped containing a-helix]]
[[Category: Omega-shaped containing a-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:50:33 2008''

Revision as of 06:50, 2 July 2008

File:1k64.png

Template:STRUCTURE 1k64

NMR Structue of alpha-conotoxin EI

Template:ABSTRACT PUBMED 11641403

About this Structure

1K64 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor., Park KH, Suk JE, Jacobsen R, Gray WR, McIntosh JM, Han KH, J Biol Chem. 2001 Dec 28;276(52):49028-33. Epub 2001 Oct 18. PMID:11641403

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