1k78: Difference between revisions

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[[Image:1k78.gif|left|200px]]
{{Seed}}
[[Image:1k78.png|left|200px]]


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{{STRUCTURE_1k78|  PDB=1k78  |  SCENE=  }}  
{{STRUCTURE_1k78|  PDB=1k78  |  SCENE=  }}  


'''Pax5(1-149)+Ets-1(331-440)+DNA'''
===Pax5(1-149)+Ets-1(331-440)+DNA===




==Overview==
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Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
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{{ABSTRACT_PUBMED_11779502}}


==Disease==
==Disease==
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[[Category: Paired domain]]
[[Category: Paired domain]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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