Sandbox Reserved 1768: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 21: | Line 21: | ||
=== Significant Residues === | === Significant Residues === | ||
The vast majority of residues involved in bile salt uptake are also involved in HBV/HDV infection. <scene name='95/952696/Residues_84- | The vast majority of residues involved in bile salt uptake are also involved in HBV/HDV infection. <scene name='95/952696/Residues_84-87_1/1'>Residues 84-87</scene> of Human NTCP have been shown to be vital for preS1 domain recognition along with bile salt uptake. Residues 157-165 (INSERT GREEN LINK) have also been shown to be vital for preS1 recognition and bile salt uptake. Altering residues in either of these two sections hinders preS1 binding and therefore HBV/HDV infection. However, these mutations also prevent bile salt uptake. | ||
== Molecular Mechanism == | == Molecular Mechanism == | ||
