Sandbox Reserved 1774

This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795.

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<StructureSection load='7t9i' size='340' side='right' caption='Thyroid Stimulating Hormone Receptor (TSHR)' scene='95/952702/Tshr_overview/1'>

Thyroid Stimulating Hormone Receptor (TSHR) Structure and Function

Introduction

Insert background about TSHR here.

Structural Overview

Describe the domains here.

Activation

Hinge Motion

Describe the hinge motion and biological function here. This morph shows the TSHR hinge movement. This TextToBeDisplayed shows the TSHR hinge movement. Morph, wireframe RNA.

1. File:TSHR MorphBetterAngle.mp4

Stabilizing Interactions in the Hinge

Describe important structural features of the hinge here. linker region hinge helix p10 region

Ligand Binding

Ligand-induced Conformation Change

Describe how TSH binds in the upright conformation here.

Ligand Recognition

Describe seatbelt and hinge important to ligand recognition here.