Sandbox Reserved 1769: Difference between revisions

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== Structure ==

Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies, revealing two key conformations in NTCP's transport mechanism. There are nine ~~transmembrane~~ [https://en.wikipedia.org/wiki/Alpha_helix alpha helices] ~~traversing~~ the ~~plasma~~ membrane, with the [https://en.wikipedia.org/wiki/N-terminus N-terminus] located on the extracellular side of the plasma membrane and the [https://en.wikipedia.org/wiki/C-terminus C-terminus] located on the intracellular side. The panel domain is formed by transmembrane helices TM1, TM5, and TM6. The core domain is formed by the packing of a helix bundle consisting of TM2, TM3, and TM4 with another helix bundle consisting of TM7, TM8, and TM9. ~~The~~ two helix bundles are related by pseudo two-fold symmetry. Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.

Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies, revealing two key conformations in NTCP's transport mechanism. There are nine [https://en.wikipedia.org/wiki/Alpha_helix alpha helices] spanning the membrane, with the [https://en.wikipedia.org/wiki/N-terminus N-terminus] located on the extracellular side of the plasma membrane and the [https://en.wikipedia.org/wiki/C-terminus C-terminus] located on the intracellular side. The panel domain is formed by transmembrane helices TM1, TM5, and TM6. The core domain is formed by the packing of a helix bundle consisting of TM2, TM3, and TM4 with another helix bundle consisting of TM7, TM8, and TM9. These two helix bundles are related by pseudo two-fold symmetry. Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.

=== Domains ===

Sandbox Reserved 1769: Difference between revisions

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 == Structure ==
-Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies, revealing two key conformations in NTCP's transport mechanism. There are nine transmembrane [https://en.wikipedia.org/wiki/Alpha_helix alpha helices] traversing the plasma membrane, with the [https://en.wikipedia.org/wiki/N-terminus N-terminus] located on the extracellular side of the plasma membrane and the [https://en.wikipedia.org/wiki/C-terminus C-terminus] located on the intracellular side. The panel domain is formed by transmembrane helices TM1, TM5, and TM6. The core domain is formed by the packing of a helix bundle consisting of TM2, TM3, and TM4 with another helix bundle consisting of TM7, TM8, and TM9. The two helix bundles are related by pseudo two-fold symmetry. Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.
+Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies, revealing two key conformations in NTCP's transport mechanism. There are nine [https://en.wikipedia.org/wiki/Alpha_helix alpha helices] spanning the membrane, with the [https://en.wikipedia.org/wiki/N-terminus N-terminus] located on the extracellular side of the plasma membrane and the [https://en.wikipedia.org/wiki/C-terminus C-terminus] located on the intracellular side. The panel domain is formed by transmembrane helices TM1, TM5, and TM6. The core domain is formed by the packing of a helix bundle consisting of TM2, TM3, and TM4 with another helix bundle consisting of TM7, TM8, and TM9. These two helix bundles are related by pseudo two-fold symmetry. Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.
 === Domains ===