Sandbox Reserved 1782: Difference between revisions
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=== Binding Pocket === | === Binding Pocket === | ||
*The NTCP binding pocket represents a "tunnel" lined with hydrophilic residues within the NTCP structure to allow hydrophilic bile salts and sodium ions to bind. When there are no bile salts bound to NTCP's <scene name='95/952710/Tunnel_front/1'>Binding Tunnel</scene>, it forms a hollow hole in the middle of the structure. As bile salts bind to this binding pocket, the bile salts very nicely fill the hole within NTCP and fit almost perfectly within the tunnel. | *The NTCP binding pocket represents a "tunnel" lined with hydrophilic residues within the NTCP structure to allow hydrophilic bile salts and sodium ions to bind. When there are no bile salts bound to NTCP's <scene name='95/952710/Tunnel_front/1'>Front of the Binding Tunnel</scene><scene name='95/952710/Tunnel_front/2'>Back of the Binding Tunnel</scene>, it forms a hollow hole in the middle of the structure. As bile salts bind to this binding pocket, the bile salts very nicely fill the hole within NTCP and fit almost perfectly within the tunnel. | ||
== Mechanism == | == Mechanism == | ||
