Sandbox Reserved 1776: Difference between revisions

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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

~~You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~

== Introduction ==

=== Biological Introduction ===

SHOC2-PP1C-MRAS is a human enzyme that is involved in regulating cell proliferation and division<ref name=”Astrain”>PMID:35356965</ref>.

SHOC2-PP1C-MRAS is a human enzyme that is involved in regulating cell proliferation and division<ref name=”Astrain”>PMID:35356965</ref>. The enzyme is involved in the vast RAS-MAPK pathway, which is initially activated by an extracellular growth factor binding to a membrane bound RAS GTPase[https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/] such as HRAS, NRAS, or KRAS. RAS-GTPases are a family of proteins that work by functioning as molecular switches. This occurs from the protein alternating between binding GTP to be active and GDP to be inactive <ref name="Astrain" />. After activation via an extracellular growth factor, the RAS-GTPase enzyme binds GTP, which activates RAF<ref>DOI:10.1016/S1556-0864(15)31506-9</ref>.

=== Structural Introduction ===

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== Relevance ==

test reference<Ref name='Molina'>Molina JR, Adjei AA. The Ras/Raf/MAPK pathway. J Thorac Oncol. 2006 Jan;1(1):7-9. [https://doi.org/10.1016/S1556-0864(15)31506-9. DOI:10.1016/S1556-0864(15)31506-9]. </Ref>

== Structural highlights ==

Sandbox Reserved 1776: Difference between revisions

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 <StructureSection load='7UPI' size='350' frame='true' side='right' caption='SHOC2-PP1C-MRAS holoenzyme complex' scene=''>
 This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Introduction ==
 === Biological Introduction ===
-SHOC2-PP1C-MRAS is a human enzyme that is involved in regulating cell proliferation and division<ref name=”Astrain”>PMID:35356965</ref>.
+SHOC2-PP1C-MRAS is a human enzyme that is involved in regulating cell proliferation and division<ref name=”Astrain”>PMID:35356965</ref>. The enzyme is involved in the vast RAS-MAPK pathway, which is initially activated by an extracellular growth factor binding to a membrane bound RAS GTPase[https://www.mechanobio.info/what-is-mechanosignaling/what-are-small-gtpases/what-are-ras-gtpases/] such as HRAS, NRAS, or KRAS. RAS-GTPases are a family of proteins that work by functioning as molecular switches. This occurs from the protein alternating between binding GTP to be active and GDP to be inactive <ref name="Astrain" />. After activation via an extracellular growth factor, the RAS-GTPase enzyme binds GTP, which activates RAF<ref>DOI:10.1016/S1556-0864(15)31506-9</ref>.
 === Structural Introduction ===
@@ Line 18: / Line 19: @@
 == Relevance ==
+test reference<Ref name='Molina'>Molina JR, Adjei AA. The Ras/Raf/MAPK pathway. J Thorac Oncol. 2006 Jan;1(1):7-9. [https://doi.org/10.1016/S1556-0864(15)31506-9. DOI:10.1016/S1556-0864(15)31506-9]. </Ref>
 == Structural highlights ==