1k8p: Difference between revisions

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[[Image:1k8p.gif|left|200px]]
{{Seed}}
[[Image:1k8p.png|left|200px]]


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{{STRUCTURE_1k8p|  PDB=1k8p  |  SCENE=  }}  
{{STRUCTURE_1k8p|  PDB=1k8p  |  SCENE=  }}  


'''Structure of the Human G-quadruplex reveals a novel topology'''
===Structure of the Human G-quadruplex reveals a novel topology===




==Overview==
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Telomeric ends of chromosomes, which comprise noncoding repeat sequences of guanine-rich DNA, are fundamental in protecting the cell from recombination and degradation. Disruption of telomere maintenance leads to eventual cell death, which can be exploited for therapeutic intervention in cancer. Telomeric DNA sequences can form four-stranded (quadruplex) structures, which may be involved in the structure of telomere ends. Here we describe the crystal structure of a quadruplex formed from four consecutive human telomeric DNA repeats and grown at a K(+) concentration that approximates its intracellular concentration. K(+) ions are observed in the structure. The folding and appearance of the DNA in this intramolecular quadruplex is fundamentally different from the published Na(+)-containing quadruplex structures. All four DNA strands are parallel, with the three linking trinucleotide loops positioned on the exterior of the quadruplex core, in a propeller-like arrangement. The adenine in each TTA linking trinucleotide loop is swung back so that it intercalates between the two thymines. This DNA structure suggests a straightforward path for telomere folding and unfolding, as well as ways in which it can recognize telomere-associated proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_12050675}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12050675 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12050675}}


==About this Structure==
==About this Structure==
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[[Category: Parallel stranded]]
[[Category: Parallel stranded]]
[[Category: Quadruplex dna]]
[[Category: Quadruplex dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:23 2008''

Revision as of 06:57, 2 July 2008

File:1k8p.png

Template:STRUCTURE 1k8p

Structure of the Human G-quadruplex reveals a novel topology

Template:ABSTRACT PUBMED 12050675

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of parallel quadruplexes from human telomeric DNA., Parkinson GN, Lee MP, Neidle S, Nature. 2002 Jun 20;417(6891):876-80. Epub 2002 May 26. PMID:12050675

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