1k8s: Difference between revisions

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[[Image:1k8s.gif|left|200px]]
{{Seed}}
[[Image:1k8s.png|left|200px]]


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{{STRUCTURE_1k8s|  PDB=1k8s  |  SCENE=  }}  
{{STRUCTURE_1k8s|  PDB=1k8s  |  SCENE=  }}  


'''BULGED ADENOSINE IN AN RNA DUPLEX'''
===BULGED ADENOSINE IN AN RNA DUPLEX===




==Overview==
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Bulges are common structural motifs in RNA secondary structure and are thought to play important roles in RNA-protein and RNA-drug interactions. Adenosine bases are the most commonly occurring unpaired base in double helical RNA secondary structures. The solution conformation and dynamics of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy and MORASS iterative relaxation matrix structural refinement. The results show that the bulged adenosine residue stacks into the RNA duplex with little perturbation around the bulged region. Most of the bases in the RNA duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker as found in the A form helices. The sugars of the bulged residue and the 5' flanking residue to it are found to exhibit C(2)'-endo conformation. None of the residues are in syn conformation.
The line below this paragraph, {{ABSTRACT_PUBMED_10903860}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10903860 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10903860}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].  


==Reference==
==Reference==
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[[Category: Bulged rna]]
[[Category: Bulged rna]]
[[Category: Rna bulge]]
[[Category: Rna bulge]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:31 2008''

Revision as of 06:57, 2 July 2008

File:1k8s.png

Template:STRUCTURE 1k8s

BULGED ADENOSINE IN AN RNA DUPLEX

Template:ABSTRACT PUBMED 10903860

About this Structure

Full experimental information is available from OCA.

Reference

Solution conformation of a bulged adenosine base in an RNA duplex by relaxation matrix refinement., Thiviyanathan V, Guliaev AB, Leontis NB, Gorenstein DG, J Mol Biol. 2000 Jul 28;300(5):1143-54. PMID:10903860

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