1k8v: Difference between revisions

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[[Image:1k8v.jpg|left|200px]]
{{Seed}}
[[Image:1k8v.png|left|200px]]


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{{STRUCTURE_1k8v|  PDB=1k8v  |  SCENE=  }}  
{{STRUCTURE_1k8v|  PDB=1k8v  |  SCENE=  }}  


'''The NMR-derived Conformation of Neuropeptide F from Moniezia expansa'''
===The NMR-derived Conformation of Neuropeptide F from Moniezia expansa===




==Overview==
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The solution structure of neuropeptide F (NPF), from the flatworm (platyhelminthes) Moniezia expansa, has been determined by (1)H NMR spectroscopy at 800 MHz in 60%/40% CD(3)OH/H(2)O. NPF is the most abundant neuropeptide in platyhelminthes. The secondary structure of NPF contains an alpha helix from residues Lys(14) to Ile(31), while the N terminus, consisting of residues Pro(-2) to Asn(13), and the C-terminus, consisting of residues Gly(32) to Phe(36), are in a random conformation. The structure was calculated by a simulated annealing protocol, and the conformational data are compared to the porcine neuropeptide Y (NPY), a peptide hormone and neurotransmitter. The exact function of NPF is unknown, but structural similarity with porcine NPY indicates that its mode of action is similar. These structural data can serve as a starting point in the design of new antiparasitic drugs.
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{{ABSTRACT_PUBMED_12023801}}


==About this Structure==
==About this Structure==
1K8V is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8V OCA].  
1K8V is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8V OCA].  


==Reference==
==Reference==
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[[Category: Neuropeptide f]]
[[Category: Neuropeptide f]]
[[Category: Npf]]
[[Category: Npf]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:26:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:52 2008''
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