1k8w: Difference between revisions

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[[Image:1k8w.~~gif~~|left|200px]]

[[Image:1k8w.png|left|200px]]

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~~'''~~Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA~~'''~~

===Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA===

~~==Overview==~~

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~~Pseudouridine (Psi) synthases catalyze~~ the ~~isomerization of specific uridines in cellular RNAs~~ to ~~pseudouridines and may function~~ as ~~RNA chaperones. TruB is responsible for the Psi residue present in the T loops of virtually all tRNAs. The close homolog Cbf5~~/~~dyskerin is the catalytic subunit of box H~~/~~ACA snoRNPs~~. ~~These carry out the pseudouridylation of eukaryotic rRNA and snRNAs~~. ~~The 1.85 A resolution structure of TruB bound to RNA reveals that this enzyme recognizes the preformed three-dimensional structure of the T loop~~, ~~primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out~~ the ~~nucleotide and disrupts the tertiary structure of tRNA. Structural comparisons with TruB demonstrate that all Psi synthases are descended from a common molecular ancestor~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11779468}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11779468 is the PubMed ID number.

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==About this Structure==

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[[Category: T stem-loop]]

[[Category: Trna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 22:26:59 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:57:57 2008''

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-[[Image:1k8w.gif|left|200px]]
+{{Seed}}
+[[Image:1k8w.png|left|200px]]
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 {{STRUCTURE_1k8w|  PDB=1k8w  |  SCENE=  }}
-'''Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA'''
+===Crystal structure of the E. coli pseudouridine synthase TruB bound to a T stem-loop RNA===
-==Overview==
+<!--
-Pseudouridine (Psi) synthases catalyze the isomerization of specific uridines in cellular RNAs to pseudouridines and may function as RNA chaperones. TruB is responsible for the Psi residue present in the T loops of virtually all tRNAs. The close homolog Cbf5/dyskerin is the catalytic subunit of box H/ACA snoRNPs. These carry out the pseudouridylation of eukaryotic rRNA and snRNAs. The 1.85 A resolution structure of TruB bound to RNA reveals that this enzyme recognizes the preformed three-dimensional structure of the T loop, primarily through shape complementarity. It accesses its substrate uridyl residue by flipping out the nucleotide and disrupts the tertiary structure of tRNA. Structural comparisons with TruB demonstrate that all Psi synthases are descended from a common molecular ancestor.
+The line below this paragraph, {{ABSTRACT_PUBMED_11779468}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11779468 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11779468}}
 ==About this Structure==
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 [[Category: T stem-loop]]
 [[Category: Trna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:26:59 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 09:57:57 2008''