1k9u: Difference between revisions

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[[Image:1k9u.jpg|left|200px]]
{{Seed}}
[[Image:1k9u.png|left|200px]]


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{{STRUCTURE_1k9u|  PDB=1k9u  |  SCENE=  }}  
{{STRUCTURE_1k9u|  PDB=1k9u  |  SCENE=  }}  


'''Crystal Structure of the Calcium-Binding Pollen Allergen Phl p 7 (Polcalcin) at 1.75 Angstroem'''
===Crystal Structure of the Calcium-Binding Pollen Allergen Phl p 7 (Polcalcin) at 1.75 Angstroem===




==Overview==
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The timothy grass pollen allergen Phl p 7 assembles most of the IgE epitopes of a novel family of 2 EF-hand calcium-binding proteins and therefore represents a diagnostic marker allergen and vaccine candidate for immunotherapy. Here we report the first three-dimensional structure of a representative of the 2 EF-hand allergen family, Phl p 7, in the calcium-bound form. The protein occurs as a novel dimer assembly with unique features: in contrast to well known EF-hand proteins such as calmodulin, parvalbumin or the S100 proteins, Phl p 7 adopts an extended conformation. Two protein monomers assemble in a head-to-tail arrangement with domain-swapped EF-hand pairing. The intertwined dimer adopts a barrel-like structure with an extended hydrophobic cavity providing a ligand-binding site. Calcium binding acts as a conformational switch between an open and a closed dimeric form of Phl p 7. These findings are interesting in the context of lipid- and calcium-dependent pollen tube growth. Furthermore, the structure of Phl p 7 allows for the rational development of vaccine strategies for treatment of sensitized allergic patients.
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{{ABSTRACT_PUBMED_12356717}}


==About this Structure==
==About this Structure==
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[[Category: Ef-hand]]
[[Category: Ef-hand]]
[[Category: Pollen allergen]]
[[Category: Pollen allergen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:29:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:00:32 2008''

Revision as of 07:00, 2 July 2008

File:1k9u.png

Template:STRUCTURE 1k9u

Crystal Structure of the Calcium-Binding Pollen Allergen Phl p 7 (Polcalcin) at 1.75 Angstroem

Template:ABSTRACT PUBMED 12356717

About this Structure

1K9U is a Single protein structure of sequence from Phleum pratense. Full crystallographic information is available from OCA.

Reference

The cross-reactive calcium-binding pollen allergen, Phl p 7, reveals a novel dimer assembly., Verdino P, Westritschnig K, Valenta R, Keller W, EMBO J. 2002 Oct 1;21(19):5007-16. PMID:12356717

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