Sandbox Reserved 1792: Difference between revisions
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== Structure== | == Structure== | ||
TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the TSH-TSHR-G<sub>s</sub> Complex. | TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name='95/952720/Tsh-tshr-gs_complex/1'>TSH-TSHR-G<sub>s</sub> Complex</scene>. | ||
<scene name='95/952720/Structure_overview/2'>TSHR has 3 main domains</scene>: Leucine Rich Region Domain (coral), the hinge region (blue-purple), and the transmembrane region. The (rainbow). The leucine rich region domain is located on the outside of the cell. This is where TSH will bind. The hinge region is also extracellular. Conformational changes in this region are responsible for the switch between the [[active vs inactive state]]. Finally, the transmembrane region is located within the plasma membrane. Its function is to hold the receptor into the membrane. This domain is also bound to the G-proteins. | <scene name='95/952720/Structure_overview/2'>TSHR has 3 main domains</scene>: Leucine Rich Region Domain (coral), the hinge region (blue-purple), and the transmembrane region. The (rainbow). The leucine rich region domain is located on the outside of the cell. This is where TSH will bind. The hinge region is also extracellular. Conformational changes in this region are responsible for the switch between the [[active vs inactive state]]. Finally, the transmembrane region is located within the plasma membrane. Its function is to hold the receptor into the membrane. This domain is also bound to the G-proteins. | ||
=== Transmembrane Region=== | === Transmembrane Region=== | ||
