Sandbox Reserved 1774: Difference between revisions

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== Biological Significance of TSHR ==

The HPT signaling axis involves the brain, thyroid gland, and bloodstream circulation. In the first step of the pathway, thyrotropin releasing hormone (TRH) is secreted by the hypothalamus, which in turn stimulates the anterior pituitary gland to produce TSH <ref name="Brent" />. TSH binds to TSHR on the surface of thyroid cells and triggers the production of thyroid hormones thyroxine (T3) and triiodothyronine (T4) through G-protein coupled receptor (GPCR) signaling <ref name="Chu">Chu YD, Yeh CT. The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. Cells. 2020;9(7):1730. [https://doi.org/10.3390/cells9071730 DOI:10.3390/cells9071730</ref>. T3 and T4 are released into the bloodstream circulation and help to regulate metabolism, including through negative feedback loop inhibition of further TSH production <ref name="Brent" />.

The HPT signaling axis involves the brain, thyroid gland, and bloodstream circulation. In the first step of the pathway, thyrotropin releasing hormone (TRH) is secreted by the hypothalamus, which in turn stimulates the anterior pituitary gland to produce TSH <ref name="Brent" />. TSH binds to TSHR on the surface of thyroid cells and triggers the production of thyroid hormones thyroxine (T3) and triiodothyronine (T4) through G-protein coupled receptor (GPCR) signaling <ref name="Chu">Chu YD, Yeh CT. The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. Cells. 2020;9(7):1730. [https://doi.org/10.3390/cells9071730 DOI:10.3390/cells9071730]</ref>. T3 and T4 are released into the bloodstream circulation and help to regulate metabolism, including through negative feedback loop inhibition of further TSH production <ref name="Brent" />.

The Malfunction of TSHR, or its TSH ligand, can lead to disease. In Grave's disease, production of a

Sandbox Reserved 1774: Difference between revisions

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 == Biological Significance of TSHR ==
-The HPT signaling axis involves the brain, thyroid gland, and bloodstream circulation. In the first step of the pathway, thyrotropin releasing hormone (TRH) is secreted by the hypothalamus, which in turn stimulates the anterior pituitary gland to produce TSH <ref name="Brent" />. TSH binds to TSHR on the surface of thyroid cells and triggers the production of thyroid hormones thyroxine (T3) and triiodothyronine (T4) through G-protein coupled receptor (GPCR) signaling <ref name="Chu">Chu YD, Yeh CT. The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. Cells. 2020;9(7):1730. [https://doi.org/10.3390/cells9071730 DOI:10.3390/cells9071730</ref>. T3 and T4 are released into the bloodstream circulation and help to regulate metabolism, including through negative feedback loop inhibition of further TSH production <ref name="Brent" />.
+The HPT signaling axis involves the brain, thyroid gland, and bloodstream circulation. In the first step of the pathway, thyrotropin releasing hormone (TRH) is secreted by the hypothalamus, which in turn stimulates the anterior pituitary gland to produce TSH <ref name="Brent" />. TSH binds to TSHR on the surface of thyroid cells and triggers the production of thyroid hormones thyroxine (T3) and triiodothyronine (T4) through G-protein coupled receptor (GPCR) signaling <ref name="Chu">Chu YD, Yeh CT. The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells. Cells. 2020;9(7):1730. [https://doi.org/10.3390/cells9071730 DOI:10.3390/cells9071730]</ref>. T3 and T4 are released into the bloodstream circulation and help to regulate metabolism, including through negative feedback loop inhibition of further TSH production <ref name="Brent" />.
 The Malfunction of TSHR, or its TSH ligand, can lead to disease. In Grave's disease, production of a