Sandbox Reserved 1769: Difference between revisions
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=== Mechanism of Bile Salt Uptake === | === Mechanism of Bile Salt Uptake === | ||
Human NTCP utilizes secondary active transport to uptake bile salts from blood into the cytoplasm of liver cells. NTCP is crucial for bile salt homeostasis. Specific substrate binding pockets for bile salts have not been identified on NTCP, so the exact mechanism of uptake is unknown. However, it is known that bile salts recognize and bind to the <scene name='95/952697/Ntcp_open-pore_state_surface/1'>open-pore state</scene>. After binding, bile salts pass through the amphipathic pore (INSERT GREEN LINK). and NTCP transitions into the <scene name='95/952697/Ntcp_inward_facing_state/1'>inward facing state</scene>. In this conformation, the pore closes off relative to the extracellular side and opens to the cytoplasmic side. Transition to the inward facing state allows release of bile salts and sodium ions. It is not yet known how this transition exactly proceeds. | |||
[[Image:Bile_Salt_Mechanism.png|450 px|right|thumb|Mechanism of Bile Salt Uptake by NTCP.]] | [[Image:Bile_Salt_Mechanism.png|450 px|right|thumb|Mechanism of Bile Salt Uptake by NTCP.]] | ||
