Sandbox Reserved 1769: Difference between revisions

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== Introduction ==

Sodium-taurocholate Co-transporting Polypeptide (NTCP) is a member of the solute carrier membrane transport proteins. It is found within the membrane of [[Image:Bile Salt.png|300 px|right|thumb|~~Image~~ of a ~~Bile Salt found in the liver~~.]][https://en.wikipedia.org/wiki/Hepatocyte hepatocytes], and its primary role is to facilitate the transport of [https://en.wikipedia.org/wiki/Bile_acid bile salts] (Figure 1) into hepatocytes from the bloodstream.<Ref name="Goutam"> Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N. Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022 Jun;606(7916):1015-1020. [https://dx.doi.org/10.1038/s41586-022-04723-z DOI: 10.1038/s41586-022-04723-z]. </Ref> This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile acids to solubilize fats for digestion. In addition to transporting bile acids into the cytoplasm of hepatocytes, NTCP also serves as a receptor for [https://en.wikipedia.org/wiki/Hepatitis_B Hepatitis B (HBV)] and [https://en.wikipedia.org/wiki/Hepatitis_D Hepatitis D (HDV)] viruses.<Ref name="Asami"> Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of the bile acid transporter and HBV receptor NTCP. Nature. 2022 Jun; 606 (7916):1021-1026. [https://dx.doi.org/10.1038/s41586-022-04845-4 DOI: 10.1038/s41586-022-04845-4]. </Ref> (Insert 2D picture from the powerpoint for basic mechanism of both bile salt and HBV)

Sodium-taurocholate Co-transporting Polypeptide (NTCP) is a member of the solute carrier membrane transport proteins. It is found within the membrane of [[Image:Bile Salt.png|300 px|right|thumb|Figure 1. Structure of Cholic Acid, an example of a bile acid.]][https://en.wikipedia.org/wiki/Hepatocyte hepatocytes], and its primary role is to facilitate the transport of [https://en.wikipedia.org/wiki/Bile_acid bile salts] (Figure 1) into hepatocytes from the bloodstream.<Ref name="Goutam"> Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N. Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022 Jun;606(7916):1015-1020. [https://dx.doi.org/10.1038/s41586-022-04723-z DOI: 10.1038/s41586-022-04723-z]. </Ref> This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile acids to solubilize fats for digestion. In addition to transporting bile acids into the cytoplasm of hepatocytes, NTCP also serves as a receptor for [https://en.wikipedia.org/wiki/Hepatitis_B Hepatitis B (HBV)] and [https://en.wikipedia.org/wiki/Hepatitis_D Hepatitis D (HDV)] viruses.<Ref name="Asami"> Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of the bile acid transporter and HBV receptor NTCP. Nature. 2022 Jun; 606 (7916):1021-1026. [https://dx.doi.org/10.1038/s41586-022-04845-4 DOI: 10.1038/s41586-022-04845-4]. </Ref> (Insert 2D picture from the powerpoint for basic mechanism of both bile salt and HBV)

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Revision as of 15:22, 30 March 2023 view source Margaret Samm (talk \| contribs) 208 edits No edit summary ← Older edit		Revision as of 15:23, 30 March 2023 view source Margaret Samm (talk \| contribs) 208 edits No edit summary Newer edit →
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	== Introduction ==		== Introduction ==
	Sodium-taurocholate Co-transporting Polypeptide (NTCP) is a member of the solute carrier membrane transport proteins. It is found within the membrane of [[Image:Bile Salt.png\|300 px\|right\|thumb\|~~Image~~ of a ~~Bile Salt found in the liver~~.]][https://en.wikipedia.org/wiki/Hepatocyte hepatocytes], and its primary role is to facilitate the transport of [https://en.wikipedia.org/wiki/Bile_acid bile salts] (Figure 1) into hepatocytes from the bloodstream.<Ref name="Goutam"> Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N. Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022 Jun;606(7916):1015-1020. [https://dx.doi.org/10.1038/s41586-022-04723-z DOI: 10.1038/s41586-022-04723-z]. </Ref> This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile acids to solubilize fats for digestion. In addition to transporting bile acids into the cytoplasm of hepatocytes, NTCP also serves as a receptor for [https://en.wikipedia.org/wiki/Hepatitis_B Hepatitis B (HBV)] and [https://en.wikipedia.org/wiki/Hepatitis_D Hepatitis D (HDV)] viruses.<Ref name="Asami"> Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of the bile acid transporter and HBV receptor NTCP. Nature. 2022 Jun; 606 (7916):1021-1026. [https://dx.doi.org/10.1038/s41586-022-04845-4 DOI: 10.1038/s41586-022-04845-4]. </Ref> (Insert 2D picture from the powerpoint for basic mechanism of both bile salt and HBV)		Sodium-taurocholate Co-transporting Polypeptide (NTCP) is a member of the solute carrier membrane transport proteins. It is found within the membrane of [[Image:Bile Salt.png\|300 px\|right\|thumb\|Figure 1. Structure of Cholic Acid, an example of a bile acid.]][https://en.wikipedia.org/wiki/Hepatocyte hepatocytes], and its primary role is to facilitate the transport of [https://en.wikipedia.org/wiki/Bile_acid bile salts] (Figure 1) into hepatocytes from the bloodstream.<Ref name="Goutam"> Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N. Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022 Jun;606(7916):1015-1020. [https://dx.doi.org/10.1038/s41586-022-04723-z DOI: 10.1038/s41586-022-04723-z]. </Ref> This is important because 90% of human bile salts are recycled daily, so the function of NTCP is critical in providing bile acids to solubilize fats for digestion. In addition to transporting bile acids into the cytoplasm of hepatocytes, NTCP also serves as a receptor for [https://en.wikipedia.org/wiki/Hepatitis_B Hepatitis B (HBV)] and [https://en.wikipedia.org/wiki/Hepatitis_D Hepatitis D (HDV)] viruses.<Ref name="Asami"> Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of the bile acid transporter and HBV receptor NTCP. Nature. 2022 Jun; 606 (7916):1021-1026. [https://dx.doi.org/10.1038/s41586-022-04845-4 DOI: 10.1038/s41586-022-04845-4]. </Ref> (Insert 2D picture from the powerpoint for basic mechanism of both bile salt and HBV)