Sandbox Reserved 1787: Difference between revisions
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===Significance and Background=== | ===Significance and Background=== | ||
IgM is one of multiple types of Ig that exist in humans. IgM presents itself on the surface of a B cell as a B Cell Receptor (BCR). Upon binding of an antigen to the BCR, the B cell will activate, proliferate, and produce other Ig compounds. These include IgG, IgD, IgA, and IgE [https://proteopedia.org/wiki/index.php/Antibody antibodies] which all have different roles in the various forms of imune response. This means that the IgM BCR is a critical step in the beggining of an imune response. | |||
The structure of IgM was found using [https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences/protein-analysis.html Cryo-EM] to visualize each atom in the protein. | |||
===History and Discovery=== | ===History and Discovery=== | ||
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The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. Theese heavy chains form a bridge connecting the FAB fragment or variable region to the transmembrane region. They also act as a wire that the variable region can send a signal through to the intermembrane region as a cellular signal that an antigen has bound. | The constant region of IgM is made up of the 2 <scene name='95/952715/Heavy_chain/1'>heavy chains</scene>. Theese heavy chains form a bridge connecting the FAB fragment or variable region to the transmembrane region. They also act as a wire that the variable region can send a signal through to the intermembrane region as a cellular signal that an antigen has bound. | ||
<scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> | <scene name='95/952715/Alpha_beta_heavy/2'>Alpha, Beta, and Heavy chain interactions</scene> help hold the heavy chains and Ig Alpha/Beta chains together in the estracellular portion of the intermembrane region. | ||
===Variable Region=== | ===Variable Region=== | ||
