Sandbox Reserved 1775: Difference between revisions

 

There are 3 main domains of the Thyroid Stimulating Hormone Receptor. First is the <scene name='95/952703/Tmd/2'>Extracellular Domain</scene> shown in green. Region is concave in shape and is made up of primarily beta sheets and rich in Leucines. It is also called the leucine rich region. This is also the domain for key Lysine residues, which play a key role in binding. Second is the <scene name='95/952703/Tmd/4'>Transmembrane Domain</scene> shown in pink. This domain is made up of 7 helices and undergoes a conformation change upon ligand binding that activates the GPCR signal cascade (GPCR is shown in yellow). The Third region of the TSHR is the <scene name='95/952703/Tmd/3'>Hinge Region</scene> shown in orange. The Hinge Region plays a key role in the movement and stability of the TSHR.