Sandbox Reserved 1769: Difference between revisions

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== Structure ==

NTCP is a transmembrane protein found in hepatocyte cells. It consists of nine <scene name='95/952697/Ntcp_open-pore_state/12'>transmembrane alpha helices</scene>, with the N-terminus located on the extracellular side of the plasma membrane and the C-terminus located on the intracellular side (Figure 3). Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.<ref name="Asami" /> Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies. <ref name="Goutam" /> <ref name="Asami" /> <ref name="Park" /> <ref name="Liu" />

NTCP is a transmembrane protein found in hepatocyte cells. It consists of nine <scene name='95/952697/Ntcp_open-pore_state/15'>transmembrane alpha helices</scene>, with the N-terminus located on the extracellular side of the plasma membrane and the C-terminus located on the intracellular side (Figure 3). Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.<ref name="Asami" /> Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies. <ref name="Goutam" /> <ref name="Asami" /> <ref name="Park" /> <ref name="Liu" />

[[Image:topography.png|300 px|thumb|Figure 3. NTCP Topology.]]

Sandbox Reserved 1769: Difference between revisions

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 == Structure ==
-NTCP is a transmembrane protein found in hepatocyte cells. It consists of nine <scene name='95/952697/Ntcp_open-pore_state/12'>transmembrane alpha helices</scene>, with the N-terminus located on the extracellular side of the plasma membrane and the C-terminus located on the intracellular side (Figure 3). Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.<ref name="Asami" /> Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies. <ref name="Goutam" /> <ref name="Asami" /> <ref name="Park" /> <ref name="Liu" />
+NTCP is a transmembrane protein found in hepatocyte cells. It consists of nine <scene name='95/952697/Ntcp_open-pore_state/15'>transmembrane alpha helices</scene>, with the N-terminus located on the extracellular side of the plasma membrane and the C-terminus located on the intracellular side (Figure 3). Transmembrane helices are connected by short loops as well as extracellular and intracellular alpha helices that lie nearly parallel to the membrane.<ref name="Asami" /> Structures were determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy (Cryo-EM)] of NTCP in complex with antibodies or nanobodies. <ref name="Goutam" /> <ref name="Asami" /> <ref name="Park" /> <ref name="Liu" />
 [[Image:topography.png|300 px|thumb|Figure 3. NTCP Topology.]]