Sandbox Reserved 1769: Difference between revisions
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== Medical Relevance == | == Medical Relevance == | ||
Bile salts are derived from [https://en.wikipedia.org/wiki/Cholesterol cholesterol], and they serve an important role in the mechanical digestion of fats and ultimately facilitate the chemical digestion of lipids. | Bile salts are derived from [https://en.wikipedia.org/wiki/Cholesterol cholesterol], and they serve an important role in the mechanical digestion of fats and ultimately facilitate the chemical digestion of lipids. Their [https://en.wikipedia.org/wiki/Amphiphile amphipathicity] allows them to do this, solubilizing hydrophobic fats for transport in aqueous bodily fluids. Without bile salts, fats would spontaneously separate out of the aqueous solution in the duodenum and would not be accessible [https://en.wikipedia.org/wiki/Pancreatic_lipase_family#Human_pancreatic_lipase pancreatic lipase] for breakdown. Proper fat digestion requires both pancreatic lipase and bile; thus, NTCP's function in recycling bile salts is critical.<Ref name="Patton"> Patton JS, Carey MC. Watching fat digestion. Science. 1979 Apr 13;204(4389):145-8. [https://dx.doi.org/10.1126/science.432636 DOI: 10.1126/science.432636]. </Ref> | ||
Insight into NTCP's structure and function has implications for therapeutic treatment of HBV/HDV infection. For example, the inhibitory effect of Nb87 on myr-preS1 binding shows potential for therapeutics that stabilize NTCP inward facing state as [https://en.wikipedia.org/wiki/Allosteric_regulation allosteric inhibitors] of viral cell entry. <Ref name="Zhang" /> | Insight into NTCP's structure and function has implications for therapeutic treatment of HBV/HDV infection. For example, the inhibitory effect of Nb87 on myr-preS1 binding shows potential for therapeutics that stabilize NTCP inward facing state as [https://en.wikipedia.org/wiki/Allosteric_regulation allosteric inhibitors] of viral cell entry. <Ref name="Zhang" /> | ||
