1ji7: Difference between revisions

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[[Image:1ji7.gif|left|200px]]<br />

[[Image:1ji7.gif|left|200px]]<br /><applet load="1ji7" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ji7" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ji7, resolution 1.45Å" />

'''Crystal Structure of TEL SAM Polymer'''<br />

==Overview==

TEL is a transcriptional repressor that is a frequent target of, chromosomal translocations in a large number of hematalogical, malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional, regulatory proteins. The self-associating property of TEL-SAM is essential, for cell transformation in many, if not all of these diseases. Here we, show that the TEL-SAM domain forms a helical, head-to-tail polymeric, structure held together by strong intermolecular contacts, providing the, first clear demonstration that SAM domains can polymerize. Our results, also suggest a mechanism by which SAM domains could mediate the spreading, of transcriptional repression complexes along the chromosome.

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

==Disease==

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==About this Structure==

1JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].

1JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Bowie, J.U.]]

[[Category: Bowie, J U.]]

[[Category: Faham, S.]]

[[Category: Gingery, M.]]

[[Category: Kim, C.A.]]

[[Category: Kim, C A.]]

[[Category: Kim, W.]]

[[Category: Phillips, M.L.]]

[[Category: Phillips, M L.]]

[[Category: Robinson, M.A.]]

[[Category: Robinson, M A.]]

[[Category: Tran, H.H.]]

[[Category: Tran, H H.]]

[[Category: SO4]]

[[Category: helical polymer]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:40:56 ~~2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:56 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ji7.gif|left|200px]]<br />
+[[Image:1ji7.gif|left|200px]]<br /><applet load="1ji7" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ji7" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ji7, resolution 1.45&Aring;" />
 '''Crystal Structure of TEL SAM Polymer'''<br />
 ==Overview==
-TEL is a transcriptional repressor that is a frequent target of, chromosomal translocations in a large number of hematalogical, malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional, regulatory proteins. The self-associating property of TEL-SAM is essential, for cell transformation in many, if not all of these diseases. Here we, show that the TEL-SAM domain forms a helical, head-to-tail polymeric, structure held together by strong intermolecular contacts, providing the, first clear demonstration that SAM domains can polymerize. Our results, also suggest a mechanism by which SAM domains could mediate the spreading, of transcriptional repression complexes along the chromosome.
+TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].
+JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Bowie, J.U.]]
+[[Category: Bowie, J U.]]
 [[Category: Faham, S.]]
 [[Category: Gingery, M.]]
-[[Category: Kim, C.A.]]
+[[Category: Kim, C A.]]
 [[Category: Kim, W.]]
-[[Category: Phillips, M.L.]]
+[[Category: Phillips, M L.]]
-[[Category: Robinson, M.A.]]
+[[Category: Robinson, M A.]]
-[[Category: Tran, H.H.]]
+[[Category: Tran, H H.]]
 [[Category: SO4]]
 [[Category: helical polymer]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:40:56 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:56 2008''