Sandbox Reserved 1783: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 47: | Line 47: | ||
=== HBV/HDV === | === HBV/HDV === | ||
Hepatitis B and D both rely on NTCP to bind and infect | Hepatitis B and D both rely on NTCP to bind and infect the human liver. HBV/HDV uses a the same patches as bile salt uptake within NTCP to infect the liver. The myristoylated (myr) pre-S1 domain of HBV is critical for its binding within the protein. Residues 8-17 within the <scene name='95/952711/Pres1_binding_area_on_ntcp/3'>pre-S1</scene> domain were found to be most important in pre-S1 binding to NTCP. HBV/HDV uses the binding patches on the outside of the protein to successfully bind. HBV/HDV binding halts the uptake of bile salt, indicating that the tunnel formed within NTCP allows the uptake of bile salts and may also mediate the binding of HBV/HDV. [[https://www.nature.com/articles/s41586-022-04845-4]] | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
