Sandbox Reserved 1777: Difference between revisions

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Because of this complex's key role in the regulation of the MAPK-RAF pathway, minor changes can be drastic. Unregulated activation of the MAPK pathway is known to be one of the most common causes of human cancer. This is due to unchecked cell division and proliferation which are the common trademarks of cancer. Cancer is thought to be so prevalent from this pathway because mutations that stabilize the interactions of the SMP complex consequently enhances holophosphatase activity <Ref name="Jajian" />, leading to accelerated cell division.

The unregulated MAPK pathway is also thought to be responsible for a multitude of developmental disorders commonly known as RASopathies <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. Though specifics are related to the gene carrying the mutation, it can be characterized as having unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays.

The unregulated MAPK pathway is also thought to be responsible for a multitude of developmental disorders commonly known as [https://dceg.cancer.gov/research/what-we-study/rasopathies#:~:text=RASopathies%20are%20a%20group%20of,to%20grow%20and%20work%20properly. RASopathies] <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. Though specifics are related to the gene carrying the mutation, it can be characterized as having unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays.

</StructureSection>

== References ==

Sandbox Reserved 1777: Difference between revisions

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@@ Line 44: / Line 44: @@
 Because of this complex's key role in the regulation of the MAPK-RAF pathway, minor changes can be drastic. Unregulated activation of the MAPK pathway is known to be one of the most common causes of human cancer. This is due to unchecked cell division and proliferation which are the common trademarks of cancer. Cancer is thought to be so prevalent from this pathway because mutations that stabilize the interactions of the SMP complex consequently enhances holophosphatase activity <Ref name="Jajian" />, leading to accelerated cell division.
-The unregulated MAPK pathway is also thought to be responsible for a multitude of developmental disorders commonly known as RASopathies <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. Though specifics are related to the gene carrying the mutation, it can be characterized as having unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays.
+The unregulated MAPK pathway is also thought to be responsible for a multitude of developmental disorders commonly known as [https://dceg.cancer.gov/research/what-we-study/rasopathies#:~:text=RASopathies%20are%20a%20group%20of,to%20grow%20and%20work%20properly. RASopathies] <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. Though specifics are related to the gene carrying the mutation, it can be characterized as having unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays.
 </StructureSection>
 == References ==
 <references/>