1jkg: Difference between revisions

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[[Image:1jkg.gif|left|200px]]<br />

[[Image:1jkg.gif|left|200px]]<br /><applet load="1jkg" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1jkg" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1jkg, resolution 1.9Å" />

'''Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA nuclear export factor'''<br />

==Overview==

TAP-p15 heterodimers have been implicated in the export of mRNAs through, nuclear pore complexes (NPCs). We report a structural analysis of the, interaction domains of TAP and p15 in a ternary complex with a Phe-Gly, (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally, similar to the homodimeric transport factor NTF2, but unlike NTF2, it is, incompatible with either homodimerization or Ran binding. The NTF2-like, heterodimer functions as a single structural unit in recognizing an FG, repeat at a hydrophobic pocket present only on TAP and not on p15. This FG, binding site interacts synergistically with a second site at the C, terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to, different classes of transport factors.

TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a ternary complex with a Phe-Gly (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally similar to the homodimeric transport factor NTF2, but unlike NTF2, it is incompatible with either homodimerization or Ran binding. The NTF2-like heterodimer functions as a single structural unit in recognizing an FG repeat at a hydrophobic pocket present only on TAP and not on p15. This FG binding site interacts synergistically with a second site at the C terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors.

==Disease==

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==About this Structure==

1JKG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1JKG OCA].

1JKG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKG OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Braun, I.C.]]

[[Category: Braun, I C.]]

[[Category: Conti, E.]]

[[Category: Fribourg, S.]]

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[[Category: ntf2-like domain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:41:~~42 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:39 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1jkg.gif|left|200px]]<br />
+[[Image:1jkg.gif|left|200px]]<br /><applet load="1jkg" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1jkg" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1jkg, resolution 1.9&Aring;" />
 '''Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA nuclear export factor'''<br />
 ==Overview==
-TAP-p15 heterodimers have been implicated in the export of mRNAs through, nuclear pore complexes (NPCs). We report a structural analysis of the, interaction domains of TAP and p15 in a ternary complex with a Phe-Gly, (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally, similar to the homodimeric transport factor NTF2, but unlike NTF2, it is, incompatible with either homodimerization or Ran binding. The NTF2-like, heterodimer functions as a single structural unit in recognizing an FG, repeat at a hydrophobic pocket present only on TAP and not on p15. This FG, binding site interacts synergistically with a second site at the C, terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to, different classes of transport factors.
+TAP-p15 heterodimers have been implicated in the export of mRNAs through nuclear pore complexes (NPCs). We report a structural analysis of the interaction domains of TAP and p15 in a ternary complex with a Phe-Gly (FG) repeat of an NPC component. The TAP-p15 heterodimer is structurally similar to the homodimeric transport factor NTF2, but unlike NTF2, it is incompatible with either homodimerization or Ran binding. The NTF2-like heterodimer functions as a single structural unit in recognizing an FG repeat at a hydrophobic pocket present only on TAP and not on p15. This FG binding site interacts synergistically with a second site at the C terminus of TAP to mediate mRNA transport through the pore. In general, our findings suggest that FG repeats bind with a similar conformation to different classes of transport factors.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-JKG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JKG OCA].
+JKG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKG OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Braun, I.C.]]
+[[Category: Braun, I C.]]
 [[Category: Conti, E.]]
 [[Category: Fribourg, S.]]
@@ Line 23: / Line 22: @@
 [[Category: ntf2-like domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:41:42 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:39 2008''