Sandbox Reserved 1792: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Grace Lane (talk | contribs) No edit summary |
Grace Lane (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
== Introduction == | == Introduction == | ||
[[Image:Thyroid System.png|300 px|right|thumb| Fig.1 An overview of the Thyroid System source: [https://en.wikipedia.org/wiki/Thyroid_hormones Thyroid Hormones]]] | [[Image:Thyroid System.png|300 px|right|thumb| Fig.1 An overview of the Thyroid System source: [https://en.wikipedia.org/wiki/Thyroid_hormones Thyroid Hormones]]] | ||
'''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>]Fig 1. | '''Thyroid Stimulating Hormone Receptor (TSHR)''' is a type of [https://proteopedia.org/wiki/index.php/GPCRs G-Protein Coupled Receptor (GPCR)] found in human thyroid follicles. It is activated by the [https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone Thyroid Stimulating Hormone (TSH)] which is known as thyrotropin. Activation of TSHR is neccessary for activating a signaling pathway for the production of thyroid hormones such as [https://en.wikipedia.org/wiki/Triiodothyronine T<sub>3</sub>] and [https://en.wikipedia.org/wiki/Thyroid_hormones T<sub>4</sub>] (Fig 1). | ||
== Structure== | == Structure== | ||
TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/3'>TSH-TSHR-Gs Complex</scene>. | TSHR forms a complex with TSH and G<sub>s</sub> proteins. This is called the <scene name=scene name='95/952720/Tsh-tshr-gs_complex/3'>TSH-TSHR-Gs Complex</scene>. | ||
