Sandbox Reserved 1783: Difference between revisions

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[[Image:Patches.png|300 px|~~left~~|thumb|'''Figure 2.''' Surface representation of the NTCP molecule with both patches shown. Patch 1 can be seen on the left side of the molecule, whereas patch 2 is located on the right side within the binding tunnel. [PDB file 7ZYI].]]

[[Image:Patches.png|300 px|right|thumb|'''Figure 2.''' Surface representation of the NTCP molecule with both patches shown. Patch 1 can be seen on the left side of the molecule, whereas patch 2 is located on the right side within the binding tunnel. [PDB file 7ZYI].]]

=== Conformation Change ===

Line 43:

=== Bile Salt Uptake ===

Cirrhosis, commonly known as the last stage of liver disease, is due to a deficiency in the bile acid supply in the liver. Bile acid pools, as defined by Vlahcevic, are the negatively-charged precursors to bile and often are conjugated to positively-charged bile salts. This is attributed either a decrease in the production of bile salts or a large increase in the excretion of this molecule out of the cell. https://www.gastrojournal.org/article/S0016-5085(71)80053-7/~~pdf~~ Cirrhosis causes symptoms such as jaundice, abdominal pain and swelling, and swelling of the legs and feet. A patient who has type two diabetes, men, and those who have or do abuse alcohol are also more sustainable to developing Cirrhosis. This diagnosis can lead to liver failure and other life-threatening diseases, making bile salt uptake essential to liver function. ~~https://www.niddk.nih.gov/health-information/liver-disease/cirrhosis/definition-facts~~

[https://www.niddk.nih.gov/health-information/liver-disease/cirrhosis/definition-facts Cirrhosis], commonly known as the last stage of liver disease, is due to a deficiency in the bile acid supply in the liver. Bile acid pools, as defined by Vlahcevic, are the negatively-charged precursors to bile and often are conjugated to positively-charged bile salts. This is attributed either a decrease in the production of bile salts or a large increase in the excretion of this molecule out of the cell. <Ref name="Cirrhosis"> Vlahcevic, Z., Buhac, I., et al. Bile Acid Metabolism in Patients with Cirrhosis. Gastroenterology vol. 60, 491-498 (1971). [https://www.gastrojournal.org/article/S0016-5085(71)80053-7/fulltext DOI: 10.1016/S0016-5085(71)80053-7]. </Ref> Cirrhosis causes symptoms such as jaundice, abdominal pain and swelling, and swelling of the legs and feet. A patient who has type two diabetes, men, and those who have or do abuse alcohol are also more sustainable to developing Cirrhosis. This diagnosis can lead to liver failure and other life-threatening diseases, making bile salt uptake essential to liver function.

</StructureSection>

== References ==

Sandbox Reserved 1783: Difference between revisions

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@@ Line 23: / Line 23: @@
-[[Image:Patches.png|300 px|left|thumb|'''Figure 2.''' Surface representation of the NTCP molecule with both patches shown. Patch 1 can be seen on the left side of the molecule, whereas patch 2 is located on the right side within the binding tunnel. [PDB file 7ZYI].]]
+[[Image:Patches.png|300 px|right|thumb|'''Figure 2.''' Surface representation of the NTCP molecule with both patches shown. Patch 1 can be seen on the left side of the molecule, whereas patch 2 is located on the right side within the binding tunnel. [PDB file 7ZYI].]]
 === Conformation Change ===
@@ Line 43: / Line 43: @@
 === Bile Salt Uptake ===
-Cirrhosis, commonly known as the last stage of liver disease, is due to a deficiency in the bile acid supply in the liver. Bile acid pools, as defined by Vlahcevic, are the negatively-charged precursors to bile and often are conjugated to positively-charged bile salts. This is attributed either a decrease in the production of bile salts or a large increase in the excretion of this molecule out of the cell. https://www.gastrojournal.org/article/S0016-5085(71)80053-7/pdf Cirrhosis causes symptoms such as jaundice, abdominal pain and swelling, and swelling of the legs and feet. A patient who has type two diabetes, men, and those who have or do abuse alcohol are also more sustainable to developing Cirrhosis. This diagnosis can lead to liver failure and other life-threatening diseases, making bile salt uptake essential to liver function. https://www.niddk.nih.gov/health-information/liver-disease/cirrhosis/definition-facts
+[https://www.niddk.nih.gov/health-information/liver-disease/cirrhosis/definition-facts Cirrhosis], commonly known as the last stage of liver disease, is due to a deficiency in the bile acid supply in the liver. Bile acid pools, as defined by Vlahcevic, are the negatively-charged precursors to bile and often are conjugated to positively-charged bile salts. This is attributed either a decrease in the production of bile salts or a large increase in the excretion of this molecule out of the cell. <Ref name="Cirrhosis"> Vlahcevic, Z., Buhac, I., et al. Bile Acid Metabolism in Patients with Cirrhosis. Gastroenterology vol. 60, 491-498 (1971). [https://www.gastrojournal.org/article/S0016-5085(71)80053-7/fulltext DOI: 10.1016/S0016-5085(71)80053-7]. </Ref> Cirrhosis causes symptoms such as jaundice, abdominal pain and swelling, and swelling of the legs and feet. A patient who has type two diabetes, men, and those who have or do abuse alcohol are also more sustainable to developing Cirrhosis. This diagnosis can lead to liver failure and other life-threatening diseases, making bile salt uptake essential to liver function.
 </StructureSection>
 == References ==
 <references/>