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| ===TSH Agonist=== | | ===TSH Agonist=== |
| [[Image:NAG.png|200 px|left|thumb|Figure 4]]
| | This clash is caused by glycosylations of an Asn52 on the <scene name='95/952707/Tsh_7t9i/1'>α-subunit of TSH</scene>. Addition of N-acetyl glucosamine modifications create steric clashes between TSH and the cell membrane, keeping TSHR in the active state. |
| Thyroid-stimulating hormone <scene name='95/952708/Tsh_7t9i/1'>(TSH)</scene>, as previously mentioned, is a hormone that stimulates the thyroid gland to produce proteins that are vital for many metabolic pathways in the body's tissue. TSH activates the TSHR protein by binding to the concave surface of the LRRD and hinge region to keep TSHR in its active state by clashing with the membrane <ref name="Duan"> DOI:10.1038/s41586-022-05173-3</ref>. (Figure 3). This clash is caused by glycosylations of an N52 residue on the <scene name='95/952707/Tsh_7t9i/1'>alpha subunit of TSH</scene>. These modifications to the N residue are N-acetyl glucosamine modifications (Figure 4). They stick out from the alpha subunit of TSH to clash with the cell membrane and keep TSH in the active state.
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