Sandbox Reserved 1777: Difference between revisions
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The SHOC2-MRAS-PP1C complex's key role in the regulation of the MAPK-RAF pathway means that minor changes in its structure or function can have drastic biological consequences. Unregulated activation of the MAPK pathway is one of the most common causes of human cancer due to unchecked cell division and proliferation '''(REF)'''. Mutations that stabilize the interactions of the SMP complex enhances PP1C phosphatase activity <Ref name="Jajian" />, leading to increased RAF signaling and accelerated cell division. | The SHOC2-MRAS-PP1C complex's key role in the regulation of the MAPK-RAF pathway means that minor changes in its structure or function can have drastic biological consequences. Unregulated activation of the MAPK pathway is one of the most common causes of human cancer due to unchecked cell division and proliferation '''(REF)'''. Mutations that stabilize the interactions of the SMP complex enhances PP1C phosphatase activity <Ref name="Jajian" />, leading to increased RAF signaling and accelerated cell division. | ||
The unregulated MAPK pathway is also responsible for a multitude of developmental disorders commonly known as [https://dceg.cancer.gov/research/what-we-study/rasopathies#:~:text=RASopathies%20are%20a%20group%20of,to%20grow%20and%20work%20properly. RASopathies] <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation '''(WHY)'''. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. NS patients often have unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays | The unregulated MAPK pathway is also responsible for a multitude of developmental disorders commonly known as [https://dceg.cancer.gov/research/what-we-study/rasopathies#:~:text=RASopathies%20are%20a%20group%20of,to%20grow%20and%20work%20properly. RASopathies] <Ref name="Lavoie" />. One such RASopathy caused by the mutation of a RAF kinase is known as [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422 Noonan Syndrome] (NS), which enhances complex formation '''(WHY- look at ref 8)'''. NS is a genetic disorder that can prevent normal development in different parts of the body in a variety of ways. NS patients often have unusual facial characteristics, short stature, a variety of heart defects and disease, and other physical problems and developmental delays<Ref name= 'van der Burgt'> van der Burgt, I. Noonan syndrome. Orphanet J Rare Dis 2, 4 (2007). doi: 10.1186/1750-1172-2-4 [https://doi.org/10.1186/1750-1172-2-4. DOI: 10.1186/1750-1172-2-4]. </Ref>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
