Sandbox Reserved 1777: Difference between revisions

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==SHOC2==

[[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size="2"><div style="text-align: center;">'''Figure 2'''. Surface representation of SHOC2-PP1C-MRAS ([https://www.rcsb.org/structure/7UPI PDB 7upi]). SHOC2 (blue), PP1C (orange) and MRAS (green). </div></font>]]

SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS '''(REF)''', serving as an aggregation point for these 3 signaling proteins. <scene name='95/952705/Shoc2_structure/1'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR motifs</scene>. LRR motifs form an an extended β sheet on the inner concave surface of SHOC2 with alpha helices facing outward, '''which help bind the whole protein'''. These LRR motifs result in a largely hydrophobic core '''within the concaved region'''.<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>.

SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS '''(REF)''', serving as an aggregation point for these 3 signaling proteins. <scene name='95/952705/Shoc2_structure/1'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR motifs</scene>. LRR motifs form an an extended β-sheet on the inner concave surface of SHOC2 with alpha helices facing outward, '''which help bind the whole protein'''. These LRR motifs result in a largely hydrophobic core '''within the concaved region'''.<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>.

==PP1C==

Sandbox Reserved 1777: Difference between revisions

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@@ Line 14: / Line 14: @@
 ==SHOC2==
 [[Image:SHOC2-PP1C-MRAS Surface.JPG|300px|right|thumb|<font size="2"><div style="text-align: center;">'''Figure 2'''. Surface representation of SHOC2-PP1C-MRAS ([https://www.rcsb.org/structure/7UPI PDB 7upi]). SHOC2 (blue), PP1C (orange) and MRAS (green).  </div></font>]]
-SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS '''(REF)''', serving as an aggregation point for these 3 signaling proteins. <scene name='95/952705/Shoc2_structure/1'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR motifs</scene>. LRR motifs form an an extended β sheet on the inner concave surface of SHOC2 with alpha helices facing outward, '''which help bind the whole protein'''. These LRR motifs result in a largely hydrophobic core '''within the concaved region'''.<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>.
+SHOC2 is a scaffolding protein which acts as a cradle to bind PP1C and MRAS '''(REF)''', serving as an aggregation point for these 3 signaling proteins. <scene name='95/952705/Shoc2_structure/1'>SHOC2</scene> is a leucine rich repeat ([https://en.wikipedia.org/wiki/Leucine-rich_repeat LRR]) protein consisting of 20 consecutive <scene name='95/952706/Shoc2_structure/6'>LRR motifs</scene>. LRR motifs form an an extended β-sheet on the inner concave surface of SHOC2 with alpha helices facing outward, '''which help bind the whole protein'''. These LRR motifs result in a largely hydrophobic core '''within the concaved region'''.<Ref name= 'Hahn'> Kwon, J. J., & Hahn, W. C. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Molecular and cellular biology, 41(4), e00627-20 (2021). doi:10.1128/MCB.00627-20. [http://doi.org/10.1128/MCB.00627-20. DOI: 10.1128/MCB.00627-20]. </Ref>.
 ==PP1C==