1w3a: Difference between revisions
New page: left|200px<br /> <applet load="1w3a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w3a, resolution 2.65Å" /> '''THREE DIMENSIONAL S... |
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==About this Structure== | ==About this Structure== | ||
1W3A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Laetiporus_sulphureus Laetiporus sulphureus]] with LBT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3A OCA]]. | 1W3A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Laetiporus_sulphureus Laetiporus sulphureus]] with LBT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3A OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: pore-forming toxin]] | [[Category: pore-forming toxin]] | ||
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Revision as of 09:37, 30 October 2007
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THREE DIMENSIONAL STRUCTURE OF A NOVEL PORE-FORMING LECTIN FROM THE MUSHROOM LAETIPORUS SULPHUREUS
Overview
LSL is a lectin produced by the parasitic mushroom Laetiporus sulphureus, which exhibits hemolytic and hemagglutinating activities. Here, we report, the crystal structure of LSL refined to 2.6-A resolution determined by the, single isomorphous replacement method with the anomalous scatter (SIRAS), signal of a platinum derivative. The structure reveals that LSL is, hexameric, which was also shown by analytical ultracentrifugation. The, monomeric protein (35 kDa) consists of two distinct modules: an N-terminal, lectin module and a pore-forming module. The lectin module has a, beta-trefoil scaffold that bears structural similarities to those present, in toxins known to interact with galactose-related carbohydrates such as, the hemagglutinin component (HA1) of the progenitor toxin from ... [(full description)]
About this Structure
1W3A is a [Single protein] structure of sequence from [Laetiporus sulphureus] with LBT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural analysis of the Laetiporus sulphureus hemolytic pore-forming lectin in complex with sugars., Mancheno JM, Tateno H, Goldstein IJ, Martinez-Ripoll M, Hermoso JA, J Biol Chem. 2005 Apr 29;280(17):17251-9. Epub 2005 Feb 1. PMID:15687495
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