1kj3: Difference between revisions

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[[Image:1kj3.jpg|left|200px]]
{{Seed}}
[[Image:1kj3.png|left|200px]]


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{{STRUCTURE_1kj3|  PDB=1kj3  |  SCENE=  }}  
{{STRUCTURE_1kj3|  PDB=1kj3  |  SCENE=  }}  


'''Mhc Class I H-2Kb molecule complexed with pKB1 peptide'''
===Mhc Class I H-2Kb molecule complexed with pKB1 peptide===




==Overview==
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The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site.
The line below this paragraph, {{ABSTRACT_PUBMED_11911820}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11911820 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11911820}}


==About this Structure==
==About this Structure==
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[[Category: Mhc class i]]
[[Category: Mhc class i]]
[[Category: Pmhc complex]]
[[Category: Pmhc complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:48:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:25:13 2008''
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